An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

Min Li; Jin Liu; Xuefei Chen; Yijing Dang; Yong Shao; Zhiai Xu; Wen Zhang

doi:10.1039/d1cc04640c

An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

Min Li
, Jin Liu
, Xuefei Chen
, Yijing Dang
, Yong Shao
, Zhiai Xu^*
, Wen Zhang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An activatable and tumor-targeting near-infrared (NIR) fluorescent probe CyAc-RGD was synthesized for the imaging of histone deacetylase 6 (HDAC6). The probe exhibited higher sensitivity and specificity for HDAC6 detection in cancer cells. Moreover, CyAc-RGD demonstrated good tumor-targeting ability and realized HDAC6 imaging in vivo.

Original language	English
Pages (from-to)	1938-1941
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	12
DOIs	https://doi.org/10.1039/d1cc04640c
State	Published - 11 Feb 2022

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10.1039/d1cc04640c

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title = "An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo",

abstract = "An activatable and tumor-targeting near-infrared (NIR) fluorescent probe CyAc-RGD was synthesized for the imaging of histone deacetylase 6 (HDAC6). The probe exhibited higher sensitivity and specificity for HDAC6 detection in cancer cells. Moreover, CyAc-RGD demonstrated good tumor-targeting ability and realized HDAC6 imaging in vivo.",

author = "Min Li and Jin Liu and Xuefei Chen and Yijing Dang and Yong Shao and Zhiai Xu and Wen Zhang",

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doi = "10.1039/d1cc04640c",

language = "英语",

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T1 - An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

AU - Li, Min

AU - Liu, Jin

AU - Chen, Xuefei

AU - Dang, Yijing

AU - Shao, Yong

AU - Xu, Zhiai

AU - Zhang, Wen

PY - 2022/2/11

Y1 - 2022/2/11

N2 - An activatable and tumor-targeting near-infrared (NIR) fluorescent probe CyAc-RGD was synthesized for the imaging of histone deacetylase 6 (HDAC6). The probe exhibited higher sensitivity and specificity for HDAC6 detection in cancer cells. Moreover, CyAc-RGD demonstrated good tumor-targeting ability and realized HDAC6 imaging in vivo.

AB - An activatable and tumor-targeting near-infrared (NIR) fluorescent probe CyAc-RGD was synthesized for the imaging of histone deacetylase 6 (HDAC6). The probe exhibited higher sensitivity and specificity for HDAC6 detection in cancer cells. Moreover, CyAc-RGD demonstrated good tumor-targeting ability and realized HDAC6 imaging in vivo.

UR - https://www.scopus.com/pages/publications/85124438113

U2 - 10.1039/d1cc04640c

DO - 10.1039/d1cc04640c

M3 - 文章

C2 - 35043795

AN - SCOPUS:85124438113

SN - 1359-7345

VL - 58

SP - 1938

EP - 1941

JO - Chemical Communications

JF - Chemical Communications

IS - 12

ER -

An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

Abstract

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