AMPK activators as novel therapeutics for type 2 diabetes

Li Fang Yu; Bei Ying Qiu; Fa Jun Nan; Jia Li

doi:10.2174/156802610790980611

AMPK activators as novel therapeutics for type 2 diabetes

Li Fang Yu
, Bei Ying Qiu
, Fa Jun Nan^*
, Jia Li

^*Corresponding author for this work

CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

AMPK is a potential target of metabolic diseases including obesity and type 2 diabetes. The activation of AMPK can lead to an increase of glucose uptake into muscle, decreased gluconeogenesis in liver, increased fatty acid oxidation in muscle and liver, decreased fatty acid synthesis in liver and adipose tissue, and increase mitochondrial biogenesis. Until now, many efforts from industrial and academia have been focused on searching novel agents that activate AMPK directly or indirectly. This review will discuss recent advances in the search for novel therapeutic agents that mediate their activity via AMPK activation.

Original language	English
Pages (from-to)	397-410
Number of pages	14
Journal	Current Topics in Medicinal Chemistry
Volume	10
Issue number	4
DOIs	https://doi.org/10.2174/156802610790980611
State	Published - Mar 2010
Externally published	Yes

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10.2174/156802610790980611

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title = "AMPK activators as novel therapeutics for type 2 diabetes",

abstract = "AMPK is a potential target of metabolic diseases including obesity and type 2 diabetes. The activation of AMPK can lead to an increase of glucose uptake into muscle, decreased gluconeogenesis in liver, increased fatty acid oxidation in muscle and liver, decreased fatty acid synthesis in liver and adipose tissue, and increase mitochondrial biogenesis. Until now, many efforts from industrial and academia have been focused on searching novel agents that activate AMPK directly or indirectly. This review will discuss recent advances in the search for novel therapeutic agents that mediate their activity via AMPK activation.",

author = "Yu, \{Li Fang\} and Qiu, \{Bei Ying\} and Nan, \{Fa Jun\} and Jia Li",

year = "2010",

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AU - Yu, Li Fang

AU - Qiu, Bei Ying

AU - Nan, Fa Jun

AU - Li, Jia

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N2 - AMPK is a potential target of metabolic diseases including obesity and type 2 diabetes. The activation of AMPK can lead to an increase of glucose uptake into muscle, decreased gluconeogenesis in liver, increased fatty acid oxidation in muscle and liver, decreased fatty acid synthesis in liver and adipose tissue, and increase mitochondrial biogenesis. Until now, many efforts from industrial and academia have been focused on searching novel agents that activate AMPK directly or indirectly. This review will discuss recent advances in the search for novel therapeutic agents that mediate their activity via AMPK activation.

AB - AMPK is a potential target of metabolic diseases including obesity and type 2 diabetes. The activation of AMPK can lead to an increase of glucose uptake into muscle, decreased gluconeogenesis in liver, increased fatty acid oxidation in muscle and liver, decreased fatty acid synthesis in liver and adipose tissue, and increase mitochondrial biogenesis. Until now, many efforts from industrial and academia have been focused on searching novel agents that activate AMPK directly or indirectly. This review will discuss recent advances in the search for novel therapeutic agents that mediate their activity via AMPK activation.

UR - https://www.scopus.com/pages/publications/77949471535

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DO - 10.2174/156802610790980611

M3 - 文献综述

C2 - 20180761

AN - SCOPUS:77949471535

SN - 1568-0266

VL - 10

SP - 397

EP - 410

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 4

ER -

AMPK activators as novel therapeutics for type 2 diabetes

Abstract

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