Amphipathic poly-β-peptides for intracellular protein delivery

Qianyi Ren; Qi Chen; Lanfang Ren; Chuntao Cao; Runhui Liu; Yiyun Cheng

doi:10.1039/d2cc00453d

Amphipathic poly-β-peptides for intracellular protein delivery

Qianyi Ren
, Qi Chen
, Lanfang Ren
, Chuntao Cao
, Runhui Liu^*
, Yiyun Cheng^*

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

Original language	English
Pages (from-to)	4320-4323
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	27
DOIs	https://doi.org/10.1039/d2cc00453d
State	Published - 8 Mar 2022

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10.1039/d2cc00453d

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title = "Amphipathic poly-β-peptides for intracellular protein delivery",

abstract = "A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.",

author = "Qianyi Ren and Qi Chen and Lanfang Ren and Chuntao Cao and Runhui Liu and Yiyun Cheng",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry",

year = "2022",

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doi = "10.1039/d2cc00453d",

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T1 - Amphipathic poly-β-peptides for intracellular protein delivery

AU - Ren, Qianyi

AU - Chen, Qi

AU - Ren, Lanfang

AU - Cao, Chuntao

AU - Liu, Runhui

AU - Cheng, Yiyun

PY - 2022/3/8

Y1 - 2022/3/8

N2 - A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

AB - A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

UR - https://www.scopus.com/pages/publications/85127574505

U2 - 10.1039/d2cc00453d

DO - 10.1039/d2cc00453d

M3 - 文章

C2 - 35293911

AN - SCOPUS:85127574505

SN - 1359-7345

VL - 58

SP - 4320

EP - 4323

JO - Chemical Communications

JF - Chemical Communications

IS - 27

ER -

Amphipathic poly-β-peptides for intracellular protein delivery

Abstract

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