Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Xu Ni Cao; Li Lin; Yu Yan Zhou; Guo Yue Shi; Wen Zhang; Katsunobu Yamamoto; Li Tong Jin

doi:10.1016/S0039-9140(03)00187-5

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Xu Ni Cao
, Li Lin
, Yu Yan Zhou
, Guo Yue Shi
, Wen Zhang
, Katsunobu Yamamoto
, Li Tong Jin^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Wenzhou Medical University
BAS Co., Ltd.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10^-7 to 1.0 × 10^-4 mol 1^-1 with the calculated detection limit (S/N = 3) of 2.0 × 10^-7 mol 1^-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

Original language	English
Pages (from-to)	1063-1070
Number of pages	8
Journal	Talanta
Volume	60
Issue number	5
DOIs	https://doi.org/10.1016/S0039-9140(03)00187-5
State	Published - 27 Jul 2003

Keywords

6-Mercaptopurine
Carbon nanotubes
Microdialysis
Pharmacokinetics
Rabbit blood

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Cao, X. N., Lin, L., Zhou, Y. Y., Shi, G. Y., Zhang, W., Yamamoto, K., & Jin, L. T. (2003). Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit. Talanta, 60(5), 1063-1070. https://doi.org/10.1016/S0039-9140(03)00187-5

@article{2e90874d358e41668167e3faaa2c03f5,

title = "Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit",

abstract = "In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.",

keywords = "6-Mercaptopurine, Carbon nanotubes, Microdialysis, Pharmacokinetics, Rabbit blood",

author = "Cao, \{Xu Ni\} and Li Lin and Zhou, \{Yu Yan\} and Shi, \{Guo Yue\} and Wen Zhang and Katsunobu Yamamoto and Jin, \{Li Tong\}",

year = "2003",

month = jul,

day = "27",

doi = "10.1016/S0039-9140(03)00187-5",

language = "英语",

volume = "60",

pages = "1063--1070",

journal = "Talanta",

issn = "0039-9140",

publisher = "Elsevier B.V.",

number = "5",

}

Cao, XN, Lin, L, Zhou, YY, Shi, GY , Zhang, W, Yamamoto, K & Jin, LT 2003, 'Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit', Talanta, vol. 60, no. 5, pp. 1063-1070. https://doi.org/10.1016/S0039-9140(03)00187-5

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit. / Cao, Xu Ni; Lin, Li; Zhou, Yu Yan et al.
In: Talanta, Vol. 60, No. 5, 27.07.2003, p. 1063-1070.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

AU - Cao, Xu Ni

AU - Lin, Li

AU - Zhou, Yu Yan

AU - Shi, Guo Yue

AU - Zhang, Wen

AU - Yamamoto, Katsunobu

AU - Jin, Li Tong

PY - 2003/7/27

Y1 - 2003/7/27

N2 - In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

AB - In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

KW - 6-Mercaptopurine

KW - Carbon nanotubes

KW - Microdialysis

KW - Pharmacokinetics

KW - Rabbit blood

UR - https://www.scopus.com/pages/publications/0042307270

U2 - 10.1016/S0039-9140(03)00187-5

DO - 10.1016/S0039-9140(03)00187-5

M3 - 文章

AN - SCOPUS:0042307270

SN - 0039-9140

VL - 60

SP - 1063

EP - 1070

JO - Talanta

JF - Talanta

IS - 5

ER -

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Abstract

Keywords

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