Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Xu Ni Cao; Li Lin; Yu Yan Zhou; Guo Yue Shi; Wen Zhang; Katsunobu Yamamoto; Li Tong Jin

doi:10.1016/S0039-9140(03)00187-5

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Xu Ni Cao, Li Lin, Yu Yan Zhou, Guo Yue Shi, Wen Zhang, Katsunobu Yamamoto, Li Tong Jin

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10^-7 to 1.0 × 10^-4 mol 1^-1 with the calculated detection limit (S/N = 3) of 2.0 × 10^-7 mol 1^-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

Original language	English
Pages (from-to)	1063-1070
Number of pages	8
Journal	Talanta
Volume	60
Issue number	5
DOIs	https://doi.org/10.1016/S0039-9140(03)00187-5
State	Published - 27 Jul 2003

Keywords

6-Mercaptopurine
Carbon nanotubes
Microdialysis
Pharmacokinetics
Rabbit blood

Access to Document

10.1016/S0039-9140(03)00187-5

Fingerprint

Dive into the research topics of 'Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit'. Together they form a unique fingerprint.

Cite this

Cao, X. N., Lin, L., Zhou, Y. Y., Shi, G. Y., Zhang, W., Yamamoto, K., & Jin, L. T. (2003). Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit. Talanta, 60(5), 1063-1070. https://doi.org/10.1016/S0039-9140(03)00187-5

@article{2e90874d358e41668167e3faaa2c03f5,

title = "Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit",

abstract = "In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.",

keywords = "6-Mercaptopurine, Carbon nanotubes, Microdialysis, Pharmacokinetics, Rabbit blood",

author = "Cao, \{Xu Ni\} and Li Lin and Zhou, \{Yu Yan\} and Shi, \{Guo Yue\} and Wen Zhang and Katsunobu Yamamoto and Jin, \{Li Tong\}",

year = "2003",

month = jul,

day = "27",

doi = "10.1016/S0039-9140(03)00187-5",

language = "英语",

volume = "60",

pages = "1063--1070",

journal = "Talanta",

issn = "0039-9140",

publisher = "Elsevier B.V.",

number = "5",

}

Cao, XN, Lin, L, Zhou, YY, Shi, GY , Zhang, W, Yamamoto, K & Jin, LT 2003, 'Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit', Talanta, vol. 60, no. 5, pp. 1063-1070. https://doi.org/10.1016/S0039-9140(03)00187-5

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit. / Cao, Xu Ni; Lin, Li; Zhou, Yu Yan et al.
In: Talanta, Vol. 60, No. 5, 27.07.2003, p. 1063-1070.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

AU - Cao, Xu Ni

AU - Lin, Li

AU - Zhou, Yu Yan

AU - Shi, Guo Yue

AU - Zhang, Wen

AU - Yamamoto, Katsunobu

AU - Jin, Li Tong

PY - 2003/7/27

Y1 - 2003/7/27

N2 - In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

AB - In this paper, multi-wall carbon nanotubes fuctionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 × 10-7 to 1.0 × 10-4 mol 1-1 with the calculated detection limit (S/N = 3) of 2.0 × 10-7 mol 1-1. Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.

KW - 6-Mercaptopurine

KW - Carbon nanotubes

KW - Microdialysis

KW - Pharmacokinetics

KW - Rabbit blood

UR - https://www.scopus.com/pages/publications/0042307270

U2 - 10.1016/S0039-9140(03)00187-5

DO - 10.1016/S0039-9140(03)00187-5

M3 - 文章

AN - SCOPUS:0042307270

SN - 0039-9140

VL - 60

SP - 1063

EP - 1070

JO - Talanta

JF - Talanta

IS - 5

ER -

Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this