TY - JOUR
T1 - Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2-Aminopyrimidines with Selectfluor
AU - Wang, Chenxi
AU - Cai, Juewang
AU - Zhang, Min
AU - Zhao, Xiaoming
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2017/1/20
Y1 - 2017/1/20
N2 - A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into N-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methylbenzenesulfonamide is discussed, and the reaction mechanism is investigated, as well.
AB - A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into N-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methylbenzenesulfonamide is discussed, and the reaction mechanism is investigated, as well.
UR - https://www.scopus.com/pages/publications/85018668759
U2 - 10.1021/acs.joc.6b02624
DO - 10.1021/acs.joc.6b02624
M3 - 文章
C2 - 28002944
AN - SCOPUS:85018668759
SN - 0022-3263
VL - 82
SP - 1260
EP - 1265
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 2
ER -