Advances in understanding the role of transient receptor potential channel ion channels in vascular remodeling

Transient receptor potential channel (TRPC) family, which functions as a non-selective cation channel, allows the entry of Na⁺ and Ca ²⁺ ions into the cells. Different homomeric or heteromeric TRPC channels regulate various physiological functions in smooth muscle and endothelial cells of blood vessel. Abnormal TRPC expressions, which is the important underlying molecular mechanism of vascular remodeling, may be responsible for pathophysiological processes of hypertension as well as increased endothelial permeability. Thus, investigating the roles of TRPC ion channels in the pathogenesis of vascular remodeling provides new therapeutic approach to the related disease.