TY - JOUR
T1 - Advances in landscape and related therapeutic targets of the prostate tumor microenvironment
AU - Li, Duocai
AU - Xu, Weidong
AU - Chang, Yifan
AU - Xiao, Yutian
AU - He, Yundong
AU - Ren, Shancheng
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - The distinct tumor microenvironment (TME) of prostate cancer (PCa), which promotes tumor proliferation and progression, consists of various stromal cells, immune cells, and a dense extracellular matrix (ECM). The understanding of the prostate TME extends to tertiary lymphoid structures (TLSs) and metastasis niches to provide a more concise comprehension of tumor metastasis. These constituents collectively structure the hallmarks of the pro-tumor TME, including immunosuppressive, acidic, and hypoxic niches, neuronal innervation, and metabolic rewiring. In combination with the knowledge of the tumor microenvironment and the advancement of emerging therapeutic technologies, several therapeutic strategies have been developed, and some of them have been tested inclinicaltrials.ThisreviewelaboratesonPCaTMEcomponents,summarizesvariousTME-targetedtherapies,and provides insights into PCa carcinogenesis, progression, and therapeutic strategies.
AB - The distinct tumor microenvironment (TME) of prostate cancer (PCa), which promotes tumor proliferation and progression, consists of various stromal cells, immune cells, and a dense extracellular matrix (ECM). The understanding of the prostate TME extends to tertiary lymphoid structures (TLSs) and metastasis niches to provide a more concise comprehension of tumor metastasis. These constituents collectively structure the hallmarks of the pro-tumor TME, including immunosuppressive, acidic, and hypoxic niches, neuronal innervation, and metabolic rewiring. In combination with the knowledge of the tumor microenvironment and the advancement of emerging therapeutic technologies, several therapeutic strategies have been developed, and some of them have been tested inclinicaltrials.ThisreviewelaboratesonPCaTMEcomponents,summarizesvariousTME-targetedtherapies,and provides insights into PCa carcinogenesis, progression, and therapeutic strategies.
KW - hallmarks
KW - immunotherapy
KW - prostate cancer
KW - tumor microenvironment
KW - tumor-associated macrophages
UR - https://www.scopus.com/pages/publications/85164243506
U2 - 10.3724/abbs.2023092
DO - 10.3724/abbs.2023092
M3 - 文献综述
C2 - 37294106
AN - SCOPUS:85164243506
SN - 1672-9145
VL - 55
SP - 956
EP - 973
JO - Acta Biochimica et Biophysica Sinica
JF - Acta Biochimica et Biophysica Sinica
IS - 6
ER -
