TY - JOUR
T1 - Advancements in life-on-a-chip
T2 - The impact of “Beyond Limits Manufacturing” technology
AU - He, Weiwei
AU - Zhang, Hongbo
AU - Lin, Xudong
AU - Zhu, Lili
AU - Zheng, Tingting
AU - Pei, Hao
AU - Tian, Yang
AU - Zhang, Min
AU - Shi, Guoyue
AU - Wu, Lei
AU - Zhao, Jianlong
AU - Wumaier, Gulinuer
AU - Li, Shengqing
AU - Xu, Yufang
AU - Li, Honglin
AU - Qian, Xuhong
N1 - Publisher Copyright:
© 2024
PY - 2024/5
Y1 - 2024/5
N2 - This review explores the concept of life-on-a-chip, which involves the creation of miniaturized biological systems, such as organs, tissues, and model organisms, on microscale platforms called microfluidic chips. These chips consist of intricately etched channels, wells, and chambers that enable precise control and observation of fluids, cells, and biochemical reactions, facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli, drugs, or disease conditions. The review highlights the application of a novel technology, “Beyond Limit Manufacturing” (BLM), in the development of sophisticated three-dimensional cell models and model organism microchips. Model-organism-on-a-chip and organ-on-a-chip (OoC) are among the thriving developments in the field of microfluidics, allowing for the reconstruction of living microenvironments and implementation of multiple stimuli. The review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions, emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.
AB - This review explores the concept of life-on-a-chip, which involves the creation of miniaturized biological systems, such as organs, tissues, and model organisms, on microscale platforms called microfluidic chips. These chips consist of intricately etched channels, wells, and chambers that enable precise control and observation of fluids, cells, and biochemical reactions, facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli, drugs, or disease conditions. The review highlights the application of a novel technology, “Beyond Limit Manufacturing” (BLM), in the development of sophisticated three-dimensional cell models and model organism microchips. Model-organism-on-a-chip and organ-on-a-chip (OoC) are among the thriving developments in the field of microfluidics, allowing for the reconstruction of living microenvironments and implementation of multiple stimuli. The review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions, emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.
KW - Beyond limit manufacturing
KW - Model-organism-on-a-chip
KW - Organ-on-a-chip
UR - https://www.scopus.com/pages/publications/85186520136
U2 - 10.1016/j.cclet.2023.109091
DO - 10.1016/j.cclet.2023.109091
M3 - 文献综述
AN - SCOPUS:85186520136
SN - 1001-8417
VL - 35
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 5
M1 - 109091
ER -
