Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

Wen Wei Qiu; Jie Xu; Jing Ya Li; Jia Li; Fa Jun Nan

doi:10.1002/cbic.200700148

Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

Wen Wei Qiu
, Jie Xu
, Jing Ya Li
, Jia Li^*
, Fa Jun Nan

^*Corresponding author for this work

CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

(Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

Original language	English
Pages (from-to)	1351-1358
Number of pages	8
Journal	ChemBioChem
Volume	8
Issue number	12
DOIs	https://doi.org/10.1002/cbic.200700148
State	Published - 13 Aug 2007
Externally published	Yes

Keywords

Azido-acetyl group
Molecular recognition
Photoaffinity labeling
Protein profiling
Trimodular probes

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10.1002/cbic.200700148

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title = "Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes",

abstract = "(Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.",

keywords = "Azido-acetyl group, Molecular recognition, Photoaffinity labeling, Protein profiling, Trimodular probes",

author = "Qiu, \{Wen Wei\} and Jie Xu and Li, \{Jing Ya\} and Jia Li and Nan, \{Fa Jun\}",

year = "2007",

month = aug,

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doi = "10.1002/cbic.200700148",

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journal = "ChemBioChem",

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T1 - Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

AU - Qiu, Wen Wei

AU - Xu, Jie

AU - Li, Jing Ya

AU - Li, Jia

AU - Nan, Fa Jun

PY - 2007/8/13

Y1 - 2007/8/13

N2 - (Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

AB - (Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

KW - Azido-acetyl group

KW - Molecular recognition

KW - Photoaffinity labeling

KW - Protein profiling

KW - Trimodular probes

UR - https://www.scopus.com/pages/publications/34548118304

U2 - 10.1002/cbic.200700148

DO - 10.1002/cbic.200700148

M3 - 文章

C2 - 17623306

AN - SCOPUS:34548118304

SN - 1439-4227

VL - 8

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EP - 1358

JO - ChemBioChem

JF - ChemBioChem

IS - 12

ER -

Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

Abstract

Keywords

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