Activators and repressers: Making use of chromatin to regulate transcription

Alan P. Wolffe; Jiemin Wong; Dmitry Pruss

doi:10.1046/j.1365-2443.1997.1260323.x

Activators and repressers: Making use of chromatin to regulate transcription

Alan P. Wolffe^*
, Jiemin Wong
, Dmitry Pruss

^*Corresponding author for this work

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Metazoans and yeast use enzymes that modulate histone acetylation and nucleosomal integrity in order to regulate transcription. Represser complexes deacetylate histones and stabilize nucleosomes. Activator complexes acetylate histones and disrupt nucleosomes. Variation in chromatin structure makes a major contribution to gene regulation. Here we discuss the enzymatic complexes and molecular machines that make use of chromatin to control transcription.

Original language	English
Pages (from-to)	291-302
Number of pages	12
Journal	Genes to Cells
Volume	2
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2443.1997.1260323.x
State	Published - 1997
Externally published	Yes

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10.1046/j.1365-2443.1997.1260323.x

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title = "Activators and repressers: Making use of chromatin to regulate transcription",

abstract = "Metazoans and yeast use enzymes that modulate histone acetylation and nucleosomal integrity in order to regulate transcription. Represser complexes deacetylate histones and stabilize nucleosomes. Activator complexes acetylate histones and disrupt nucleosomes. Variation in chromatin structure makes a major contribution to gene regulation. Here we discuss the enzymatic complexes and molecular machines that make use of chromatin to control transcription.",

author = "Wolffe, \{Alan P.\} and Jiemin Wong and Dmitry Pruss",

year = "1997",

doi = "10.1046/j.1365-2443.1997.1260323.x",

language = "英语",

volume = "2",

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journal = "Genes to Cells",

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T1 - Activators and repressers

T2 - Making use of chromatin to regulate transcription

AU - Wolffe, Alan P.

AU - Wong, Jiemin

AU - Pruss, Dmitry

PY - 1997

Y1 - 1997

N2 - Metazoans and yeast use enzymes that modulate histone acetylation and nucleosomal integrity in order to regulate transcription. Represser complexes deacetylate histones and stabilize nucleosomes. Activator complexes acetylate histones and disrupt nucleosomes. Variation in chromatin structure makes a major contribution to gene regulation. Here we discuss the enzymatic complexes and molecular machines that make use of chromatin to control transcription.

AB - Metazoans and yeast use enzymes that modulate histone acetylation and nucleosomal integrity in order to regulate transcription. Represser complexes deacetylate histones and stabilize nucleosomes. Activator complexes acetylate histones and disrupt nucleosomes. Variation in chromatin structure makes a major contribution to gene regulation. Here we discuss the enzymatic complexes and molecular machines that make use of chromatin to control transcription.

UR - https://www.scopus.com/pages/publications/0031132205

U2 - 10.1046/j.1365-2443.1997.1260323.x

DO - 10.1046/j.1365-2443.1997.1260323.x

M3 - 文章

C2 - 9280341

AN - SCOPUS:0031132205

SN - 1356-9597

VL - 2

SP - 291

EP - 302

JO - Genes to Cells

JF - Genes to Cells

IS - 5

ER -

Activators and repressers: Making use of chromatin to regulate transcription

Abstract

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