Activation of STING Based on Its Structural Features

Behzad Hussain; Yufeng Xie; Uzma Jabeen; Defen Lu; Bo Yang; Changxin Wu; Guijun Shang

doi:10.3389/fimmu.2022.808607

Activation of STING Based on Its Structural Features

Behzad Hussain
, Yufeng Xie
, Uzma Jabeen
, Defen Lu
, Bo Yang
, Changxin Wu
, Guijun Shang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.

Original language	English
Article number	808607
Journal	Frontiers in Immunology
Volume	13
DOIs	https://doi.org/10.3389/fimmu.2022.808607
State	Published - 19 Jul 2022
Externally published	Yes

Keywords

cyclic GMP-AMP
cyclic GMP-AMP Synthase (cGAS)
cyclic dinucleotide
innate immunity
stimulator of interferon genes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fimmu.2022.808607

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title = "Activation of STING Based on Its Structural Features",

abstract = "The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.",

keywords = "cyclic GMP-AMP, cyclic GMP-AMP Synthase (cGAS), cyclic dinucleotide, innate immunity, stimulator of interferon genes",

author = "Behzad Hussain and Yufeng Xie and Uzma Jabeen and Defen Lu and Bo Yang and Changxin Wu and Guijun Shang",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Hussain, Xie, Jabeen, Lu, Yang, Wu and Shang.",

year = "2022",

month = jul,

day = "19",

doi = "10.3389/fimmu.2022.808607",

language = "英语",

volume = "13",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Activation of STING Based on Its Structural Features

AU - Hussain, Behzad

AU - Xie, Yufeng

AU - Jabeen, Uzma

AU - Lu, Defen

AU - Yang, Bo

AU - Wu, Changxin

AU - Shang, Guijun

PY - 2022/7/19

Y1 - 2022/7/19

N2 - The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.

AB - The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.

KW - cyclic GMP-AMP

KW - cyclic GMP-AMP Synthase (cGAS)

KW - cyclic dinucleotide

KW - innate immunity

KW - stimulator of interferon genes

UR - https://www.scopus.com/pages/publications/85135239984

U2 - 10.3389/fimmu.2022.808607

DO - 10.3389/fimmu.2022.808607

M3 - 文献综述

C2 - 35928815

AN - SCOPUS:85135239984

SN - 1664-3224

VL - 13

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 808607

ER -

Activation of STING Based on Its Structural Features

Abstract

Keywords

UN SDGs

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