Acid-catalyzed cascade reactions of enaminones with aldehydes: C-H functionalization to afford 1, 4-dihydropyridines

Jingyu Yang; Chengyu Wang; Xin Xie; Hongfeng Li; Yanzhong Li

doi:10.1002/ejoc.201000607

Acid-catalyzed cascade reactions of enaminones with aldehydes: C-H functionalization to afford 1, 4-dihydropyridines

Jingyu Yang
, Chengyu Wang
, Xin Xie
, Hongfeng Li
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization.

Original language	English
Pages (from-to)	4189-4193
Number of pages	5
Journal	European Journal of Organic Chemistry
Issue number	22
DOIs	https://doi.org/10.1002/ejoc.201000607
State	Published - Aug 2010

Keywords

C-H activation
Cyclization
Domino reactions
Lewis acids
Nitrogen heterocycles

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10.1002/ejoc.201000607

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title = "Acid-catalyzed cascade reactions of enaminones with aldehydes: C-H functionalization to afford 1, 4-dihydropyridines",

abstract = "An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization.",

keywords = "C-H activation, Cyclization, Domino reactions, Lewis acids, Nitrogen heterocycles",

author = "Jingyu Yang and Chengyu Wang and Xin Xie and Hongfeng Li and Yanzhong Li",

year = "2010",

month = aug,

doi = "10.1002/ejoc.201000607",

language = "英语",

pages = "4189--4193",

journal = "European Journal of Organic Chemistry",

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publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Acid-catalyzed cascade reactions of enaminones with aldehydes

T2 - C-H functionalization to afford 1, 4-dihydropyridines

AU - Yang, Jingyu

AU - Wang, Chengyu

AU - Xie, Xin

AU - Li, Hongfeng

AU - Li, Yanzhong

PY - 2010/8

Y1 - 2010/8

N2 - An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization.

AB - An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization.

KW - C-H activation

KW - Cyclization

KW - Domino reactions

KW - Lewis acids

KW - Nitrogen heterocycles

UR - https://www.scopus.com/pages/publications/77954986510

U2 - 10.1002/ejoc.201000607

DO - 10.1002/ejoc.201000607

M3 - 文章

AN - SCOPUS:77954986510

SN - 1434-193X

SP - 4189

EP - 4193

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 22

ER -

Acid-catalyzed cascade reactions of enaminones with aldehydes: C-H functionalization to afford 1, 4-dihydropyridines

Abstract

Keywords

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