Abiestetranes A and B, two unique tetraterpenes from Abies fabri

Yong Li Li; Shou De Zhang; Hui Zi Jin; Jun Mian Tian; Yun Heng Shen; Xian Wen Yang; Hong Lin Li; Wei Dong Zhang

doi:10.1016/j.tet.2012.07.047

Abiestetranes A and B, two unique tetraterpenes from Abies fabri

Yong Li Li
, Shou De Zhang
, Hui Zi Jin
, Jun Mian Tian
, Yun Heng Shen
, Xian Wen Yang^*
, Hong Lin Li
, Wei Dong Zhang

^*Corresponding author for this work

Shanghai Jiao Tong University
East China University of Science and Technology
Naval Medical University
CAS - South China Sea Institute of Oceanology
Luxembourg Institute of Health

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Abiestetranes A (1) and B (2), two unique tetraterpenes formed by Diels-Alder cycloaddition between a lanostane triterpenoid and a monoterpenoid, were isolated from Abies fabri. Their structures were elucidated by extensive analysis of NMR data. The electronic circular dichroism was utilized to assign the absolute configuration of 1. Compounds 1 and 2 showed significant cytotoxic activities against ZR-75-30 tumor cell with IC ₅₀ values of 6.26 and 1.63 μg/mL, respectively.

Original language	English
Pages (from-to)	7763-7767
Number of pages	5
Journal	Tetrahedron
Volume	68
Issue number	38
DOIs	https://doi.org/10.1016/j.tet.2012.07.047
State	Published - 23 Sep 2012
Externally published	Yes

Keywords

Abies fabri
Abiestetranes A and B
Cytotoxicity
Diels-Alder cycloaddition
Pinaceae
Tetraterpenes

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10.1016/j.tet.2012.07.047

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title = "Abiestetranes A and B, two unique tetraterpenes from Abies fabri",

abstract = "Abiestetranes A (1) and B (2), two unique tetraterpenes formed by Diels-Alder cycloaddition between a lanostane triterpenoid and a monoterpenoid, were isolated from Abies fabri. Their structures were elucidated by extensive analysis of NMR data. The electronic circular dichroism was utilized to assign the absolute configuration of 1. Compounds 1 and 2 showed significant cytotoxic activities against ZR-75-30 tumor cell with IC 50 values of 6.26 and 1.63 μg/mL, respectively.",

keywords = "Abies fabri, Abiestetranes A and B, Cytotoxicity, Diels-Alder cycloaddition, Pinaceae, Tetraterpenes",

author = "Li, \{Yong Li\} and Zhang, \{Shou De\} and Jin, \{Hui Zi\} and Tian, \{Jun Mian\} and Shen, \{Yun Heng\} and Yang, \{Xian Wen\} and Li, \{Hong Lin\} and Zhang, \{Wei Dong\}",

year = "2012",

month = sep,

day = "23",

doi = "10.1016/j.tet.2012.07.047",

language = "英语",

volume = "68",

pages = "7763--7767",

journal = "Tetrahedron",

issn = "0040-4020",

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TY - JOUR

T1 - Abiestetranes A and B, two unique tetraterpenes from Abies fabri

AU - Li, Yong Li

AU - Zhang, Shou De

AU - Jin, Hui Zi

AU - Tian, Jun Mian

AU - Shen, Yun Heng

AU - Yang, Xian Wen

AU - Li, Hong Lin

AU - Zhang, Wei Dong

PY - 2012/9/23

Y1 - 2012/9/23

N2 - Abiestetranes A (1) and B (2), two unique tetraterpenes formed by Diels-Alder cycloaddition between a lanostane triterpenoid and a monoterpenoid, were isolated from Abies fabri. Their structures were elucidated by extensive analysis of NMR data. The electronic circular dichroism was utilized to assign the absolute configuration of 1. Compounds 1 and 2 showed significant cytotoxic activities against ZR-75-30 tumor cell with IC 50 values of 6.26 and 1.63 μg/mL, respectively.

AB - Abiestetranes A (1) and B (2), two unique tetraterpenes formed by Diels-Alder cycloaddition between a lanostane triterpenoid and a monoterpenoid, were isolated from Abies fabri. Their structures were elucidated by extensive analysis of NMR data. The electronic circular dichroism was utilized to assign the absolute configuration of 1. Compounds 1 and 2 showed significant cytotoxic activities against ZR-75-30 tumor cell with IC 50 values of 6.26 and 1.63 μg/mL, respectively.

KW - Abies fabri

KW - Abiestetranes A and B

KW - Cytotoxicity

KW - Diels-Alder cycloaddition

KW - Pinaceae

KW - Tetraterpenes

UR - https://www.scopus.com/pages/publications/84864626380

U2 - 10.1016/j.tet.2012.07.047

DO - 10.1016/j.tet.2012.07.047

M3 - 文章

AN - SCOPUS:84864626380

SN - 0040-4020

VL - 68

SP - 7763

EP - 7767

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

Abiestetranes A and B, two unique tetraterpenes from Abies fabri

Abstract

Keywords

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