Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

Ping Yu; Shou De Zhang; Yong Li Li; Xian Wen Yang; Hua Wu Zeng; Hong Lin Li; Wei Dong Zhang

doi:10.1002/hlca.201100341

Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

Ping Yu, Shou De Zhang, Yong Li Li, Xian Wen Yang, Hua Wu Zeng, Hong Lin Li, Wei Dong Zhang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.

Original language	English
Pages (from-to)	415-422
Number of pages	8
Journal	Helvetica Chimica Acta
Volume	95
Issue number	3
DOIs	https://doi.org/10.1002/hlca.201100341
State	Published - Mar 2012
Externally published	Yes

Keywords

Abies forrestii
Abieseconordines A and B
Density-functional theory (DFT)
Ditepenoids
Electronic circular dichroism (ECD)
Nitric oxide

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10.1002/hlca.201100341

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title = "Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii",

abstract = "A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.",

keywords = "Abies forrestii, Abieseconordines A and B, Density-functional theory (DFT), Ditepenoids, Electronic circular dichroism (ECD), Nitric oxide",

author = "Ping Yu and Zhang, \{Shou De\} and Li, \{Yong Li\} and Yang, \{Xian Wen\} and Zeng, \{Hua Wu\} and Li, \{Hong Lin\} and Zhang, \{Wei Dong\}",

year = "2012",

month = mar,

doi = "10.1002/hlca.201100341",

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volume = "95",

pages = "415--422",

journal = "Helvetica Chimica Acta",

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T1 - Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

AU - Yu, Ping

AU - Zhang, Shou De

AU - Li, Yong Li

AU - Yang, Xian Wen

AU - Zeng, Hua Wu

AU - Li, Hong Lin

AU - Zhang, Wei Dong

PY - 2012/3

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AB - A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.

KW - Abies forrestii

KW - Abieseconordines A and B

KW - Density-functional theory (DFT)

KW - Ditepenoids

KW - Electronic circular dichroism (ECD)

KW - Nitric oxide

UR - https://www.scopus.com/pages/publications/84859084910

U2 - 10.1002/hlca.201100341

DO - 10.1002/hlca.201100341

M3 - 文章

AN - SCOPUS:84859084910

SN - 0018-019X

VL - 95

SP - 415

EP - 422

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 3

ER -

Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

Abstract

Keywords

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