TY - JOUR
T1 - A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
AU - He, Haihong
AU - Xia, Yang
AU - Qi, Yingxue
AU - Wang, Hong Yin
AU - Wang, Zhuang
AU - Bao, Jianming
AU - Zhang, Ziqian
AU - Wu, Fu Gen
AU - Wang, Haolu
AU - Chen, Daijie
AU - Yang, Dahai
AU - Liang, Xiaowen
AU - Chen, Jinquan
AU - Zhou, Shengmin
AU - Liang, Xin
AU - Qian, Xuhong
AU - Yang, Youjun
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/4/18
Y1 - 2018/4/18
N2 - Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.
AB - Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.
UR - https://www.scopus.com/pages/publications/85045541903
U2 - 10.1021/acs.bioconjchem.7b00821
DO - 10.1021/acs.bioconjchem.7b00821
M3 - 文章
C2 - 29498825
AN - SCOPUS:85045541903
SN - 1043-1802
VL - 29
SP - 1194
EP - 1198
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 4
ER -