A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity

Xia Li; Jianlin Shi; Yufang Zhu; Weihua Shen; Hua Li; Jian Liang; Jianhua Gao

doi:10.1002/jbm.b.30813

A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity

Xia Li, Jianlin Shi^*, Yufang Zhu, Weihua Shen, Hua Li, Jian Liang, Jianhua Gao

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The mesoporous amorphous calcium silicate (MACS) was first synthesized using mesoporous silica SBA-15 as both the template and silicon source, and Ca(NO₃)₂ as the calcium source. The MACS shows a well-defined mesoporous structure with high specific surface area. In vitro bioactivity studies of the MACS were carried out by soaking it in simulated body fluid (SBF) solutions for 4 h up to 5 days. Owing to the high specific surface area and pore volume, the MACS had a significantly enhanced bone-forming bioactivity compared with the conventional amorphous CaSiO₃. The MACS did develop a carbonate-containing hydroxyapatite (HCA) layer on the surface after being immersed in SBF for 4 h with near-spherical agglomerated hydroxyapatite (HA) nanoparticles. At longer soaking times, the number of agglomerated HA particles increased and the surface structure of the samples became more compact. Such MACS could be useful in developing new biomaterials and may have potential use in implanting and drug delivery for tissue regeneration.

Original language	English
Pages (from-to)	431-439
Number of pages	9
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	83
Issue number	2
DOIs	https://doi.org/10.1002/jbm.b.30813
State	Published - Nov 2007
Externally published	Yes

Keywords

Bioactive material
Mineralization
Porous

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title = "A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity",

abstract = "The mesoporous amorphous calcium silicate (MACS) was first synthesized using mesoporous silica SBA-15 as both the template and silicon source, and Ca(NO3)2 as the calcium source. The MACS shows a well-defined mesoporous structure with high specific surface area. In vitro bioactivity studies of the MACS were carried out by soaking it in simulated body fluid (SBF) solutions for 4 h up to 5 days. Owing to the high specific surface area and pore volume, the MACS had a significantly enhanced bone-forming bioactivity compared with the conventional amorphous CaSiO3. The MACS did develop a carbonate-containing hydroxyapatite (HCA) layer on the surface after being immersed in SBF for 4 h with near-spherical agglomerated hydroxyapatite (HA) nanoparticles. At longer soaking times, the number of agglomerated HA particles increased and the surface structure of the samples became more compact. Such MACS could be useful in developing new biomaterials and may have potential use in implanting and drug delivery for tissue regeneration.",

keywords = "Bioactive material, Mineralization, Porous",

author = "Xia Li and Jianlin Shi and Yufang Zhu and Weihua Shen and Hua Li and Jian Liang and Jianhua Gao",

year = "2007",

month = nov,

doi = "10.1002/jbm.b.30813",

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journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",

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T1 - A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity

AU - Li, Xia

AU - Shi, Jianlin

AU - Zhu, Yufang

AU - Shen, Weihua

AU - Li, Hua

AU - Liang, Jian

AU - Gao, Jianhua

PY - 2007/11

Y1 - 2007/11

N2 - The mesoporous amorphous calcium silicate (MACS) was first synthesized using mesoporous silica SBA-15 as both the template and silicon source, and Ca(NO3)2 as the calcium source. The MACS shows a well-defined mesoporous structure with high specific surface area. In vitro bioactivity studies of the MACS were carried out by soaking it in simulated body fluid (SBF) solutions for 4 h up to 5 days. Owing to the high specific surface area and pore volume, the MACS had a significantly enhanced bone-forming bioactivity compared with the conventional amorphous CaSiO3. The MACS did develop a carbonate-containing hydroxyapatite (HCA) layer on the surface after being immersed in SBF for 4 h with near-spherical agglomerated hydroxyapatite (HA) nanoparticles. At longer soaking times, the number of agglomerated HA particles increased and the surface structure of the samples became more compact. Such MACS could be useful in developing new biomaterials and may have potential use in implanting and drug delivery for tissue regeneration.

AB - The mesoporous amorphous calcium silicate (MACS) was first synthesized using mesoporous silica SBA-15 as both the template and silicon source, and Ca(NO3)2 as the calcium source. The MACS shows a well-defined mesoporous structure with high specific surface area. In vitro bioactivity studies of the MACS were carried out by soaking it in simulated body fluid (SBF) solutions for 4 h up to 5 days. Owing to the high specific surface area and pore volume, the MACS had a significantly enhanced bone-forming bioactivity compared with the conventional amorphous CaSiO3. The MACS did develop a carbonate-containing hydroxyapatite (HCA) layer on the surface after being immersed in SBF for 4 h with near-spherical agglomerated hydroxyapatite (HA) nanoparticles. At longer soaking times, the number of agglomerated HA particles increased and the surface structure of the samples became more compact. Such MACS could be useful in developing new biomaterials and may have potential use in implanting and drug delivery for tissue regeneration.

KW - Bioactive material

KW - Mineralization

KW - Porous

UR - https://www.scopus.com/pages/publications/35548929455

U2 - 10.1002/jbm.b.30813

DO - 10.1002/jbm.b.30813

M3 - 文章

C2 - 17415771

AN - SCOPUS:35548929455

SN - 1552-4973

VL - 83

SP - 431

EP - 439

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

IS - 2

ER -

A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity

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Keywords

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