A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines

Zhu Cao; Jian Bo Zhu; Lijia Wang; Saihu Liao; Yong Tang

doi:10.1021/acs.orglett.9b01276

A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines

Zhu Cao
, Jian Bo Zhu
, Lijia Wang^*
, Saihu Liao
, Yong Tang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in good yields with excellent regioselectivity. Synthetic utility of the resulting product was demonstrated in a concise synthesis of biologically active compound Paullone.

Original language	English
Pages (from-to)	4097-4100
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	11
DOIs	https://doi.org/10.1021/acs.orglett.9b01276
State	Published - 7 Jun 2019

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10.1021/acs.orglett.9b01276

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title = "A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines",

abstract = "A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in good yields with excellent regioselectivity. Synthetic utility of the resulting product was demonstrated in a concise synthesis of biologically active compound Paullone.",

author = "Zhu Cao and Zhu, \{Jian Bo\} and Lijia Wang and Saihu Liao and Yong Tang",

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AU - Cao, Zhu

AU - Zhu, Jian Bo

AU - Wang, Lijia

AU - Liao, Saihu

AU - Tang, Yong

PY - 2019/6/7

Y1 - 2019/6/7

N2 - A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in good yields with excellent regioselectivity. Synthetic utility of the resulting product was demonstrated in a concise synthesis of biologically active compound Paullone.

AB - A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in good yields with excellent regioselectivity. Synthetic utility of the resulting product was demonstrated in a concise synthesis of biologically active compound Paullone.

UR - https://www.scopus.com/pages/publications/85066881418

U2 - 10.1021/acs.orglett.9b01276

DO - 10.1021/acs.orglett.9b01276

M3 - 文章

C2 - 31084023

AN - SCOPUS:85066881418

SN - 1523-7060

VL - 21

SP - 4097

EP - 4100

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines

Abstract

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