A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids

Wenyi Mei; Sisi Fan; Yufei Han; Cunjian Shi; Lijie Qiu; Yunheng Shen; Zhenjiang Zhao; Yufang Xu; Honglin Li

doi:10.1039/d3ob00016h

A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids

Wenyi Mei
, Sisi Fan
, Yufei Han
, Cunjian Shi
, Lijie Qiu
, Yunheng Shen
, Zhenjiang Zhao^*
, Yufang Xu^*
, Honglin Li^*

^*Corresponding author for this work

East China University of Science and Technology
Naval Medical University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Herein, we presented a simple approach for C-H oxidation in the C23 or/and C24 of ursane triterpenoids without any protection of a Δ^12,13 double bond. As a result, from commercial ursolic acid (UA), six naturally occurring ursane triterpenoids were synthesized in overall yields of 3.4% to 36.8%, which implied the importance of this approach for the derivation of natural products and their application in biological activity.

Original language	English
Pages (from-to)	1395-1398
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	21
Issue number	7
DOIs	https://doi.org/10.1039/d3ob00016h
State	Published - 13 Jan 2023
Externally published	Yes

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abstract = "Herein, we presented a simple approach for C-H oxidation in the C23 or/and C24 of ursane triterpenoids without any protection of a Δ12,13 double bond. As a result, from commercial ursolic acid (UA), six naturally occurring ursane triterpenoids were synthesized in overall yields of 3.4\% to 36.8\%, which implied the importance of this approach for the derivation of natural products and their application in biological activity.",

author = "Wenyi Mei and Sisi Fan and Yufei Han and Cunjian Shi and Lijie Qiu and Yunheng Shen and Zhenjiang Zhao and Yufang Xu and Honglin Li",

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T1 - A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids

AU - Mei, Wenyi

AU - Fan, Sisi

AU - Han, Yufei

AU - Shi, Cunjian

AU - Qiu, Lijie

AU - Shen, Yunheng

AU - Zhao, Zhenjiang

AU - Xu, Yufang

AU - Li, Honglin

PY - 2023/1/13

Y1 - 2023/1/13

N2 - Herein, we presented a simple approach for C-H oxidation in the C23 or/and C24 of ursane triterpenoids without any protection of a Δ12,13 double bond. As a result, from commercial ursolic acid (UA), six naturally occurring ursane triterpenoids were synthesized in overall yields of 3.4% to 36.8%, which implied the importance of this approach for the derivation of natural products and their application in biological activity.

AB - Herein, we presented a simple approach for C-H oxidation in the C23 or/and C24 of ursane triterpenoids without any protection of a Δ12,13 double bond. As a result, from commercial ursolic acid (UA), six naturally occurring ursane triterpenoids were synthesized in overall yields of 3.4% to 36.8%, which implied the importance of this approach for the derivation of natural products and their application in biological activity.

UR - https://www.scopus.com/pages/publications/85147173226

U2 - 10.1039/d3ob00016h

DO - 10.1039/d3ob00016h

M3 - 文章

C2 - 36688572

AN - SCOPUS:85147173226

SN - 1477-0520

VL - 21

SP - 1395

EP - 1398

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids

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