A SAMBA for chemically induced proximity

Yang Zhou; Xiaoding Ma; Haifeng Ye

doi:10.1038/s41589-025-01934-z

A SAMBA for chemically induced proximity

Yang Zhou, Xiaoding Ma, Haifeng Ye^*

^*Corresponding author for this work

School of Life Sciences

East China Normal University

Research output: Contribution to journal › Comment/debate

Abstract

SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.

Original language	English
Pages (from-to)	1310-1311
Number of pages	2
Journal	Nature Chemical Biology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1038/s41589-025-01934-z
State	Published - Sep 2025

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title = "A SAMBA for chemically induced proximity",

abstract = "SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.",

author = "Yang Zhou and Xiaoding Ma and Haifeng Ye",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc. 2025.",

year = "2025",

month = sep,

doi = "10.1038/s41589-025-01934-z",

language = "英语",

volume = "21",

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T1 - A SAMBA for chemically induced proximity

AU - Zhou, Yang

AU - Ma, Xiaoding

AU - Ye, Haifeng

PY - 2025/9

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N2 - SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.

AB - SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.

UR - https://www.scopus.com/pages/publications/105008200726

U2 - 10.1038/s41589-025-01934-z

DO - 10.1038/s41589-025-01934-z

M3 - 评论/辩论

AN - SCOPUS:105008200726

SN - 1552-4450

VL - 21

SP - 1310

EP - 1311

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 9

ER -

A SAMBA for chemically induced proximity

Abstract

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