TY - JOUR
T1 - A region-resolved mucosa proteome of the human stomach
AU - Ni, Xiaotian
AU - Tan, Zhaoli
AU - Ding, Chen
AU - Zhang, Chunchao
AU - Song, Lan
AU - Yang, Shuai
AU - Liu, Mingwei
AU - Jia, Ru
AU - Zhao, Chuanhua
AU - Song, Lei
AU - Liu, Wanlin
AU - Zhou, Quan
AU - Gong, Tongqing
AU - Li, Xianju
AU - Tai, Yanhong
AU - Zhu, Weimin
AU - Shi, Tieliu
AU - Wang, Yi
AU - Xu, Jianming
AU - Zhen, Bei
AU - Qin, Jun
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis of protein profiles of 82 apparently normal mucosa samples obtained from living individuals by endoscopic stomach biopsy. We identify 6,258 high-confidence proteins and estimate the ranges of protein expression in the seven stomach regions, presenting a region-resolved proteome reference map of the near normal, human stomach. Furthermore, we measure mucosa protein profiles of tumor and tumor nearby tissues (TNT) from 58 gastric cancer patients, enabling comparisons between tumor, TNT, and normal tissue. These datasets provide a rich resource for the gastrointestinal tract research community to investigate the molecular basis for region-specific functions in mucosa physiology and pathology including gastric cancer.
AB - The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis of protein profiles of 82 apparently normal mucosa samples obtained from living individuals by endoscopic stomach biopsy. We identify 6,258 high-confidence proteins and estimate the ranges of protein expression in the seven stomach regions, presenting a region-resolved proteome reference map of the near normal, human stomach. Furthermore, we measure mucosa protein profiles of tumor and tumor nearby tissues (TNT) from 58 gastric cancer patients, enabling comparisons between tumor, TNT, and normal tissue. These datasets provide a rich resource for the gastrointestinal tract research community to investigate the molecular basis for region-specific functions in mucosa physiology and pathology including gastric cancer.
UR - https://www.scopus.com/pages/publications/85059494691
U2 - 10.1038/s41467-018-07960-x
DO - 10.1038/s41467-018-07960-x
M3 - 文章
C2 - 30604760
AN - SCOPUS:85059494691
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 39
ER -
