A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity

Xiaojun Cai; Wei Gao; Ming Ma; Meiying Wu; Linlin Zhang; Yuanyi Zheng; Hangrong Chen; Jianlin Shi

doi:10.1002/adma.201503381

A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity

Xiaojun Cai
, Wei Gao
, Ming Ma
, Meiying Wu
, Linlin Zhang
, Yuanyi Zheng
, Hangrong Chen^*
, Jianlin Shi

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics
Second Affiliated Hospital of Chongqing Medical University

Research output: Contribution to journal › Article › peer-review

273 Scopus citations

Abstract

Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T₁-weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r₁ = 7.43 m m^-1 s^-1), and achieves the real-time monitoring of drug release.

Original language	English
Pages (from-to)	6382-6389
Number of pages	8
Journal	Advanced Materials
Volume	27
Issue number	41
DOIs	https://doi.org/10.1002/adma.201503381
State	Published - 1 Nov 2015
Externally published	Yes

Keywords

Prussian blue
magnetic resonance imaging
manganese
pH-responsive
theranostics

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10.1002/adma.201503381

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title = "A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity",

abstract = "Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1-weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m-1 s-1), and achieves the real-time monitoring of drug release.",

keywords = "Prussian blue, magnetic resonance imaging, manganese, pH-responsive, theranostics",

author = "Xiaojun Cai and Wei Gao and Ming Ma and Meiying Wu and Linlin Zhang and Yuanyi Zheng and Hangrong Chen and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

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doi = "10.1002/adma.201503381",

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T1 - A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity

AU - Cai, Xiaojun

AU - Gao, Wei

AU - Ma, Ming

AU - Wu, Meiying

AU - Zhang, Linlin

AU - Zheng, Yuanyi

AU - Chen, Hangrong

AU - Shi, Jianlin

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1-weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m-1 s-1), and achieves the real-time monitoring of drug release.

AB - Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1-weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m-1 s-1), and achieves the real-time monitoring of drug release.

KW - Prussian blue

KW - magnetic resonance imaging

KW - manganese

KW - pH-responsive

KW - theranostics

UR - https://www.scopus.com/pages/publications/84946054216

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DO - 10.1002/adma.201503381

M3 - 文章

C2 - 26393889

AN - SCOPUS:84946054216

SN - 0935-9648

VL - 27

SP - 6382

EP - 6389

JO - Advanced Materials

JF - Advanced Materials

IS - 41

ER -

A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity

Abstract

Keywords

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