A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

Qianjun He; Yu Gao; Lingxia Zhang; Zhiwen Zhang; Fang Gao; Xiufeng Ji; Yaping Li; Jianlin Shi

doi:10.1016/j.biomaterials.2011.06.066

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

Qianjun He, Yu Gao, Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li^*, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

383 Scopus citations

Abstract

A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 ± 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.

Original language	English
Pages (from-to)	7711-7720
Number of pages	10
Journal	Biomaterials
Volume	32
Issue number	30
DOIs	https://doi.org/10.1016/j.biomaterials.2011.06.066
State	Published - Oct 2011
Externally published	Yes

Keywords

Controlled drug release
Mesoporous silica
Multi-drug delivery
Multi-drug resistance
Nanoparticle
One-pot self-assembly

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2011.06.066

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title = "A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance",

abstract = "A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 ± 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.",

keywords = "Controlled drug release, Mesoporous silica, Multi-drug delivery, Multi-drug resistance, Nanoparticle, One-pot self-assembly",

author = "Qianjun He and Yu Gao and Lingxia Zhang and Zhiwen Zhang and Fang Gao and Xiufeng Ji and Yaping Li and Jianlin Shi",

year = "2011",

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doi = "10.1016/j.biomaterials.2011.06.066",

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T1 - A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

AU - He, Qianjun

AU - Gao, Yu

AU - Zhang, Lingxia

AU - Zhang, Zhiwen

AU - Gao, Fang

AU - Ji, Xiufeng

AU - Li, Yaping

AU - Shi, Jianlin

PY - 2011/10

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N2 - A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 ± 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.

AB - A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 ± 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.

KW - Controlled drug release

KW - Mesoporous silica

KW - Multi-drug delivery

KW - Multi-drug resistance

KW - Nanoparticle

KW - One-pot self-assembly

UR - https://www.scopus.com/pages/publications/80051544002

U2 - 10.1016/j.biomaterials.2011.06.066

DO - 10.1016/j.biomaterials.2011.06.066

M3 - 文章

C2 - 21816467

AN - SCOPUS:80051544002

SN - 0142-9612

VL - 32

SP - 7711

EP - 7720

JO - Biomaterials

JF - Biomaterials

IS - 30

ER -

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

Abstract

Keywords

UN SDGs

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