A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: Design, synthesis and intracellular applications

Jiaobing Wang; Yi Xiao; Zhichao Zhang; Xuhong Qian; Yuanyuan Yang; Qin Xu

doi:10.1039/b500766f

A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: Design, synthesis and intracellular applications

Jiaobing Wang^*, Yi Xiao, Zhichao Zhang, Xuhong Qian, Yuanyuan Yang, Qin Xu

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

The development and intracellular applications of a water-soluble Zn(II) sensor (WZS) are described. 4-Aminonaphthalimide is used as the fluorophore of WZS for its high photostability, long excitation and emission wavelength, large Stokes' shift and inert response to pH. N,N-Bis(2-pyridylmethyl)ethylenediamine (BPEN), used as a receptor for Zn(II), is attached to the fluorophore through a rigid benzene framework on the imide moiety. Spectroscopic studies indicate that this fluorophore-receptor linking strategy could be used for the development of effective photoinduced electron transfer (PET) sensors. WZS is pH-insensitive and shows high selectivity for Zn(II) against other biologically relevant metal ions. Cellular applications revealed that WZS could be used for the imaging of intracellular Zn(II).

Original language	English
Pages (from-to)	2836-2839
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	15
Issue number	27-28
DOIs	https://doi.org/10.1039/b500766f
State	Published - 21 Jul 2005
Externally published	Yes

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title = "A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: Design, synthesis and intracellular applications",

abstract = "The development and intracellular applications of a water-soluble Zn(II) sensor (WZS) are described. 4-Aminonaphthalimide is used as the fluorophore of WZS for its high photostability, long excitation and emission wavelength, large Stokes' shift and inert response to pH. N,N-Bis(2-pyridylmethyl)ethylenediamine (BPEN), used as a receptor for Zn(II), is attached to the fluorophore through a rigid benzene framework on the imide moiety. Spectroscopic studies indicate that this fluorophore-receptor linking strategy could be used for the development of effective photoinduced electron transfer (PET) sensors. WZS is pH-insensitive and shows high selectivity for Zn(II) against other biologically relevant metal ions. Cellular applications revealed that WZS could be used for the imaging of intracellular Zn(II).",

author = "Jiaobing Wang and Yi Xiao and Zhichao Zhang and Xuhong Qian and Yuanyuan Yang and Qin Xu",

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T1 - A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide

T2 - Design, synthesis and intracellular applications

AU - Wang, Jiaobing

AU - Xiao, Yi

AU - Zhang, Zhichao

AU - Qian, Xuhong

AU - Yang, Yuanyuan

AU - Xu, Qin

PY - 2005/7/21

Y1 - 2005/7/21

N2 - The development and intracellular applications of a water-soluble Zn(II) sensor (WZS) are described. 4-Aminonaphthalimide is used as the fluorophore of WZS for its high photostability, long excitation and emission wavelength, large Stokes' shift and inert response to pH. N,N-Bis(2-pyridylmethyl)ethylenediamine (BPEN), used as a receptor for Zn(II), is attached to the fluorophore through a rigid benzene framework on the imide moiety. Spectroscopic studies indicate that this fluorophore-receptor linking strategy could be used for the development of effective photoinduced electron transfer (PET) sensors. WZS is pH-insensitive and shows high selectivity for Zn(II) against other biologically relevant metal ions. Cellular applications revealed that WZS could be used for the imaging of intracellular Zn(II).

AB - The development and intracellular applications of a water-soluble Zn(II) sensor (WZS) are described. 4-Aminonaphthalimide is used as the fluorophore of WZS for its high photostability, long excitation and emission wavelength, large Stokes' shift and inert response to pH. N,N-Bis(2-pyridylmethyl)ethylenediamine (BPEN), used as a receptor for Zn(II), is attached to the fluorophore through a rigid benzene framework on the imide moiety. Spectroscopic studies indicate that this fluorophore-receptor linking strategy could be used for the development of effective photoinduced electron transfer (PET) sensors. WZS is pH-insensitive and shows high selectivity for Zn(II) against other biologically relevant metal ions. Cellular applications revealed that WZS could be used for the imaging of intracellular Zn(II).

UR - https://www.scopus.com/pages/publications/22944464376

U2 - 10.1039/b500766f

DO - 10.1039/b500766f

M3 - 文献综述

AN - SCOPUS:22944464376

SN - 0959-9428

VL - 15

SP - 2836

EP - 2839

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 27-28

ER -

A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: Design, synthesis and intracellular applications

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