A novel human gene expressed in heart

Kai Mei Luo; Yue Qun Wang; Hua Liang Pi; Wu Zhou Yuan; Da Li Li; Xiu Shan Wu

A novel human gene expressed in heart

Kai Mei Luo^*
, Yue Qun Wang
, Hua Liang Pi
, Wu Zhou Yuan
, Da Li Li
, Xiu Shan Wu

^*Corresponding author for this work

Hunan Normal University

Research output: Contribution to journal › Article › peer-review

Abstract

KRAB/C₂H₂-type zinc finger protein is a transcription factor with important function. We cloned a novel human KRAB/C₂ H₂-type zinc finger gene and named ZNF382 as approved by HUGO nomenclature committee. The full length of ZNF382 is 2 824 bp with 5 exons and 4 introns, which spans approximately 23 kb long in genomics. It encodes 548 amino acids containing a KRAB domain at the NH₂ terminus and a vestigial zinc finger (VZF) and 9 tandemly repeated Kruppel-type C₂ H₂ zinc finger domains (ZF) at the COOH terminus. Northern blot analysis indicates that a 2.9 kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day). ZNF382 is widely expressed in human embryo tissues, including brain, kidney, lung, heart, skeletal muscle, and adrenal. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Acta Scientiarum Naturalium Universitatis Normalis Hunanensis
Volume	26
Issue number	2
State	Published - Jun 2003
Externally published	Yes

Keywords

Clone
Expression
Heat development
KRAB/CH
ZNF382

Cite this

@article{75083b15af374aaa83abab43b166211e,

title = "A novel human gene expressed in heart",

abstract = "KRAB/C2H2-type zinc finger protein is a transcription factor with important function. We cloned a novel human KRAB/C2 H2-type zinc finger gene and named ZNF382 as approved by HUGO nomenclature committee. The full length of ZNF382 is 2 824 bp with 5 exons and 4 introns, which spans approximately 23 kb long in genomics. It encodes 548 amino acids containing a KRAB domain at the NH2 terminus and a vestigial zinc finger (VZF) and 9 tandemly repeated Kruppel-type C2 H2 zinc finger domains (ZF) at the COOH terminus. Northern blot analysis indicates that a 2.9 kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day). ZNF382 is widely expressed in human embryo tissues, including brain, kidney, lung, heart, skeletal muscle, and adrenal. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.",

keywords = "Clone, Expression, Heat development, KRAB/CH, ZNF382",

author = "Luo, \{Kai Mei\} and Wang, \{Yue Qun\} and Pi, \{Hua Liang\} and Yuan, \{Wu Zhou\} and Li, \{Da Li\} and Wu, \{Xiu Shan\}",

year = "2003",

month = jun,

language = "英语",

volume = "26",

pages = "79--83",

journal = "Acta Scientiarum Naturalium Universitatis Normalis Hunanensis",

issn = "1000-2537",

publisher = "Hunan Shifan Daxue/Hunan Normal University",

number = "2",

}

TY - JOUR

T1 - A novel human gene expressed in heart

AU - Luo, Kai Mei

AU - Wang, Yue Qun

AU - Pi, Hua Liang

AU - Yuan, Wu Zhou

AU - Li, Da Li

AU - Wu, Xiu Shan

PY - 2003/6

Y1 - 2003/6

N2 - KRAB/C2H2-type zinc finger protein is a transcription factor with important function. We cloned a novel human KRAB/C2 H2-type zinc finger gene and named ZNF382 as approved by HUGO nomenclature committee. The full length of ZNF382 is 2 824 bp with 5 exons and 4 introns, which spans approximately 23 kb long in genomics. It encodes 548 amino acids containing a KRAB domain at the NH2 terminus and a vestigial zinc finger (VZF) and 9 tandemly repeated Kruppel-type C2 H2 zinc finger domains (ZF) at the COOH terminus. Northern blot analysis indicates that a 2.9 kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day). ZNF382 is widely expressed in human embryo tissues, including brain, kidney, lung, heart, skeletal muscle, and adrenal. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

AB - KRAB/C2H2-type zinc finger protein is a transcription factor with important function. We cloned a novel human KRAB/C2 H2-type zinc finger gene and named ZNF382 as approved by HUGO nomenclature committee. The full length of ZNF382 is 2 824 bp with 5 exons and 4 introns, which spans approximately 23 kb long in genomics. It encodes 548 amino acids containing a KRAB domain at the NH2 terminus and a vestigial zinc finger (VZF) and 9 tandemly repeated Kruppel-type C2 H2 zinc finger domains (ZF) at the COOH terminus. Northern blot analysis indicates that a 2.9 kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day). ZNF382 is widely expressed in human embryo tissues, including brain, kidney, lung, heart, skeletal muscle, and adrenal. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

KW - Clone

KW - Expression

KW - Heat development

KW - KRAB/CH

KW - ZNF382

UR - https://www.scopus.com/pages/publications/0042320659

M3 - 文章

AN - SCOPUS:0042320659

SN - 1000-2537

VL - 26

SP - 79

EP - 83

JO - Acta Scientiarum Naturalium Universitatis Normalis Hunanensis

JF - Acta Scientiarum Naturalium Universitatis Normalis Hunanensis

IS - 2

ER -

A novel human gene expressed in heart

Abstract

Keywords

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