A new prodrug-derived ratiometric fluorescent probe for hypoxia: High selectivity of nitroreductase and imaging in tumor cell

Lei Cui; Ye Zhong; Weiping Zhu; Yufang Xu; Qingshan Du; Xin Wang; Xuhong Qian; Yi Xiao

doi:10.1021/ol102975t

A new prodrug-derived ratiometric fluorescent probe for hypoxia: High selectivity of nitroreductase and imaging in tumor cell

Lei Cui
, Ye Zhong
, Weiping Zhu
, Yufang Xu^*
, Qingshan Du
, Xin Wang
, Xuhong Qian
, Yi Xiao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.(Figure Presented)

Original language	English
Pages (from-to)	928-931
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	5
DOIs	https://doi.org/10.1021/ol102975t
State	Published - 4 Mar 2011
Externally published	Yes

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10.1021/ol102975t

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title = "A new prodrug-derived ratiometric fluorescent probe for hypoxia: High selectivity of nitroreductase and imaging in tumor cell",

abstract = "Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.(Figure Presented)",

author = "Lei Cui and Ye Zhong and Weiping Zhu and Yufang Xu and Qingshan Du and Xin Wang and Xuhong Qian and Yi Xiao",

year = "2011",

month = mar,

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volume = "13",

pages = "928--931",

journal = "Organic Letters",

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TY - JOUR

T1 - A new prodrug-derived ratiometric fluorescent probe for hypoxia

T2 - High selectivity of nitroreductase and imaging in tumor cell

AU - Cui, Lei

AU - Zhong, Ye

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Du, Qingshan

AU - Wang, Xin

AU - Qian, Xuhong

AU - Xiao, Yi

PY - 2011/3/4

Y1 - 2011/3/4

N2 - Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.(Figure Presented)

AB - Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.(Figure Presented)

UR - https://www.scopus.com/pages/publications/79952180923

U2 - 10.1021/ol102975t

DO - 10.1021/ol102975t

M3 - 文章

C2 - 21268631

AN - SCOPUS:79952180923

SN - 1523-7060

VL - 13

SP - 928

EP - 931

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

A new prodrug-derived ratiometric fluorescent probe for hypoxia: High selectivity of nitroreductase and imaging in tumor cell

Abstract

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