A new green titania with enhanced NIR absorption for mitochondria-targeted cancer therapy

Juan Mou; Tianquan Lin; Fuqiang Huang; Jianlin Shi; Hangrong Chen

doi:10.7150/thno.17247

A new green titania with enhanced NIR absorption for mitochondria-targeted cancer therapy

Juan Mou
, Tianquan Lin
, Fuqiang Huang
, Jianlin Shi
, Hangrong Chen^*

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A new kind of green titania (G-TiO_2-x) with obvious green color was facilely synthesized from black titania (B-TiO_2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO_2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO_2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO_2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO_2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W c_m-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO_2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.

Original language	English
Pages (from-to)	1531-1542
Number of pages	12
Journal	Theranostics
Volume	7
Issue number	6
DOIs	https://doi.org/10.7150/thno.17247
State	Published - 2017
Externally published	Yes

Keywords

Green titania
Mitochondria
NIR absorption
Photodynamic therapy
Photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "A new green titania with enhanced NIR absorption for mitochondria-targeted cancer therapy",

abstract = "A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.",

keywords = "Green titania, Mitochondria, NIR absorption, Photodynamic therapy, Photothermal therapy",

author = "Juan Mou and Tianquan Lin and Fuqiang Huang and Jianlin Shi and Hangrong Chen",

note = "Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

doi = "10.7150/thno.17247",

language = "英语",

volume = "7",

pages = "1531--1542",

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}

TY - JOUR

T1 - A new green titania with enhanced NIR absorption for mitochondria-targeted cancer therapy

AU - Mou, Juan

AU - Lin, Tianquan

AU - Huang, Fuqiang

AU - Shi, Jianlin

AU - Chen, Hangrong

N1 - Publisher Copyright: © Ivyspring International Publisher.

PY - 2017

Y1 - 2017

N2 - A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.

AB - A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.

KW - Green titania

KW - Mitochondria

KW - NIR absorption

KW - Photodynamic therapy

KW - Photothermal therapy

UR - https://www.scopus.com/pages/publications/85018498346

U2 - 10.7150/thno.17247

DO - 10.7150/thno.17247

M3 - 文章

C2 - 28529636

AN - SCOPUS:85018498346

SN - 1838-7640

VL - 7

SP - 1531

EP - 1542

JO - Theranostics

JF - Theranostics

IS - 6

ER -

A new green titania with enhanced NIR absorption for mitochondria-targeted cancer therapy

Abstract

Keywords

UN SDGs

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