A "Neck-formation" strategy for an antiquenching magnetic/upconversion fluorescent bimodal cancer probe

Feng Chen; Shengjian Zhang; Wenbo Bu; Xiaohang Liu; Yu Chen; Qianjun He; Min Zhu; Lingxia Zhang; Liangping Zhou; Weijun Peng; Jianlin Shi

doi:10.1002/chem.201000525

A "Neck-formation" strategy for an antiquenching magnetic/upconversion fluorescent bimodal cancer probe

Feng Chen^*
, Shengjian Zhang
, Wenbo Bu
, Xiaohang Liu
, Yu Chen
, Qianjun He
, Min Zhu
, Lingxia Zhang
, Liangping Zhou
, Weijun Peng
, Jianlin Shi

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics
Fudan University

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF ₄:ErYb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general "neck- formation" strategy forming a size-controlled Cd²⁺- and Gd ³⁺-free silica-shielded magnetic upconversion fluorescent oligomer (SMUFO) bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T₂-weighted magnetic resonance enhanced effect (see graphic).

Original language	English
Pages (from-to)	11254-11260
Number of pages	7
Journal	Chemistry - A European Journal
Volume	16
Issue number	37
DOIs	https://doi.org/10.1002/chem.201000525
State	Published - 4 Oct 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antitumor agents
Fluorescence
Imaging agents
Magnetic resonance imaging
Neck formation

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10.1002/chem.201000525

Cite this

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title = "A {"}Neck-formation{"} strategy for an antiquenching magnetic/upconversion fluorescent bimodal cancer probe",

abstract = "Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF 4:ErYb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general {"}neck- formation{"} strategy forming a size-controlled Cd2+- and Gd 3+-free silica-shielded magnetic upconversion fluorescent oligomer (SMUFO) bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T2-weighted magnetic resonance enhanced effect (see graphic).",

keywords = "Antitumor agents, Fluorescence, Imaging agents, Magnetic resonance imaging, Neck formation",

author = "Feng Chen and Shengjian Zhang and Wenbo Bu and Xiaohang Liu and Yu Chen and Qianjun He and Min Zhu and Lingxia Zhang and Liangping Zhou and Weijun Peng and Jianlin Shi",

year = "2010",

month = oct,

day = "4",

doi = "10.1002/chem.201000525",

language = "英语",

volume = "16",

pages = "11254--11260",

journal = "Chemistry - A European Journal",

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TY - JOUR

T1 - A "Neck-formation" strategy for an antiquenching magnetic/upconversion fluorescent bimodal cancer probe

AU - Chen, Feng

AU - Zhang, Shengjian

AU - Bu, Wenbo

AU - Liu, Xiaohang

AU - Chen, Yu

AU - He, Qianjun

AU - Zhu, Min

AU - Zhang, Lingxia

AU - Zhou, Liangping

AU - Peng, Weijun

AU - Shi, Jianlin

PY - 2010/10/4

Y1 - 2010/10/4

N2 - Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF 4:ErYb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general "neck- formation" strategy forming a size-controlled Cd2+- and Gd 3+-free silica-shielded magnetic upconversion fluorescent oligomer (SMUFO) bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T2-weighted magnetic resonance enhanced effect (see graphic).

AB - Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF 4:ErYb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general "neck- formation" strategy forming a size-controlled Cd2+- and Gd 3+-free silica-shielded magnetic upconversion fluorescent oligomer (SMUFO) bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T2-weighted magnetic resonance enhanced effect (see graphic).

KW - Antitumor agents

KW - Fluorescence

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Neck formation

UR - https://www.scopus.com/pages/publications/77957199511

U2 - 10.1002/chem.201000525

DO - 10.1002/chem.201000525

M3 - 文章

C2 - 20715197

AN - SCOPUS:77957199511

SN - 0947-6539

VL - 16

SP - 11254

EP - 11260

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 37

ER -

A "Neck-formation" strategy for an antiquenching magnetic/upconversion fluorescent bimodal cancer probe

Abstract

UN SDGs

Keywords

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