A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells

Xuan Zhang; Lun Zhang; Yaqian Liu; Bin Bao; Yi Zang; Jia Li; Wei Lu

doi:10.1016/j.tet.2015.05.025

A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells

Xuan Zhang
, Lun Zhang
, Yaqian Liu
, Bin Bao
, Yi Zang
, Jia Li^*
, Wei Lu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A new near-infrared and colorimetric fluorescent molecular probe was developed for rapid detection of H₂O₂. The near-infrared fluorescence OFF-ON switch is triggered by transformation of phenylboronic acid unit to phenol in the presence of H₂O₂. No quinone methides are released in this process, which is preferable for in vivo studies. In addition, probe 1 at low concentration exhibits high quality optical imaging during a short period in in vitro cell study.

Original language	English
Pages (from-to)	4842-4845
Number of pages	4
Journal	Tetrahedron
Volume	71
Issue number	29
DOIs	https://doi.org/10.1016/j.tet.2015.05.025
State	Published - 2015

Keywords

Hydrogen peroxide
Near-infrared
Probe
ROS

Access to Document

10.1016/j.tet.2015.05.025

Cite this

@article{d444f1b3ef404dc1a2a709871118f205,

title = "A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells",

abstract = "A new near-infrared and colorimetric fluorescent molecular probe was developed for rapid detection of H2O2. The near-infrared fluorescence OFF-ON switch is triggered by transformation of phenylboronic acid unit to phenol in the presence of H2O2. No quinone methides are released in this process, which is preferable for in vivo studies. In addition, probe 1 at low concentration exhibits high quality optical imaging during a short period in in vitro cell study.",

keywords = "Hydrogen peroxide, Near-infrared, Probe, ROS",

author = "Xuan Zhang and Lun Zhang and Yaqian Liu and Bin Bao and Yi Zang and Jia Li and Wei Lu",

year = "2015",

doi = "10.1016/j.tet.2015.05.025",

language = "英语",

volume = "71",

pages = "4842--4845",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "29",

}

TY - JOUR

T1 - A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells

AU - Zhang, Xuan

AU - Zhang, Lun

AU - Liu, Yaqian

AU - Bao, Bin

AU - Zang, Yi

AU - Li, Jia

AU - Lu, Wei

PY - 2015

Y1 - 2015

N2 - A new near-infrared and colorimetric fluorescent molecular probe was developed for rapid detection of H2O2. The near-infrared fluorescence OFF-ON switch is triggered by transformation of phenylboronic acid unit to phenol in the presence of H2O2. No quinone methides are released in this process, which is preferable for in vivo studies. In addition, probe 1 at low concentration exhibits high quality optical imaging during a short period in in vitro cell study.

AB - A new near-infrared and colorimetric fluorescent molecular probe was developed for rapid detection of H2O2. The near-infrared fluorescence OFF-ON switch is triggered by transformation of phenylboronic acid unit to phenol in the presence of H2O2. No quinone methides are released in this process, which is preferable for in vivo studies. In addition, probe 1 at low concentration exhibits high quality optical imaging during a short period in in vitro cell study.

KW - Hydrogen peroxide

KW - Near-infrared

KW - Probe

KW - ROS

UR - https://www.scopus.com/pages/publications/84937152419

U2 - 10.1016/j.tet.2015.05.025

DO - 10.1016/j.tet.2015.05.025

M3 - 文章

AN - SCOPUS:84937152419

SN - 0040-4020

VL - 71

SP - 4842

EP - 4845

JO - Tetrahedron

JF - Tetrahedron

IS - 29

ER -

A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this