A multifunctional core-shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy

Fei Zhou; Tingting Zheng; E. S. Abdel-Halim; Liping Jiang; Jun Jie Zhu

doi:10.1039/c6tb00438e

A multifunctional core-shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy

Fei Zhou
, Tingting Zheng
, E. S. Abdel-Halim
, Liping Jiang^*
, Jun Jie Zhu

^*Corresponding author for this work

Nanjing University
King Saud University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO₂) nanosheets to induce enhanced cancer cell apoptosis. MnO₂ nanosheets fabricated on the surface of AgNPs served as efficient fluorescence quenchers of Dox. After being internalized into cancer cells, the fluorescence of Dox could be turned on gradually by intracellular glutathione (GSH) which reduces MnO₂ into Mn²⁺ to release Dox. The synergetic effects of AgNP-induced apoptosis and subsequent Dox delivery resulted in enhanced cancer cell apoptosis. Annexin V-FITC/PI double staining, mitochondrial membrane potential (MMP) detection and reactive oxygen species (ROS) detection demonstrated the specific enhanced apoptosis of cancer cells. In this way, the novel nanoprobes can be used as promising theranostic agents for specific cancer therapy.

Original language	English
Pages (from-to)	2887-2894
Number of pages	8
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	17
DOIs	https://doi.org/10.1039/c6tb00438e
State	Published - 2016
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1039/c6tb00438e

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title = "A multifunctional core-shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy",

abstract = "A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis. MnO2 nanosheets fabricated on the surface of AgNPs served as efficient fluorescence quenchers of Dox. After being internalized into cancer cells, the fluorescence of Dox could be turned on gradually by intracellular glutathione (GSH) which reduces MnO2 into Mn2+ to release Dox. The synergetic effects of AgNP-induced apoptosis and subsequent Dox delivery resulted in enhanced cancer cell apoptosis. Annexin V-FITC/PI double staining, mitochondrial membrane potential (MMP) detection and reactive oxygen species (ROS) detection demonstrated the specific enhanced apoptosis of cancer cells. In this way, the novel nanoprobes can be used as promising theranostic agents for specific cancer therapy.",

author = "Fei Zhou and Tingting Zheng and Abdel-Halim, \{E. S.\} and Liping Jiang and Zhu, \{Jun Jie\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6tb00438e",

language = "英语",

volume = "4",

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journal = "Journal of Materials Chemistry B",

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}

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T1 - A multifunctional core-shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy

AU - Zhou, Fei

AU - Zheng, Tingting

AU - Abdel-Halim, E. S.

AU - Jiang, Liping

AU - Zhu, Jun Jie

PY - 2016

Y1 - 2016

N2 - A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis. MnO2 nanosheets fabricated on the surface of AgNPs served as efficient fluorescence quenchers of Dox. After being internalized into cancer cells, the fluorescence of Dox could be turned on gradually by intracellular glutathione (GSH) which reduces MnO2 into Mn2+ to release Dox. The synergetic effects of AgNP-induced apoptosis and subsequent Dox delivery resulted in enhanced cancer cell apoptosis. Annexin V-FITC/PI double staining, mitochondrial membrane potential (MMP) detection and reactive oxygen species (ROS) detection demonstrated the specific enhanced apoptosis of cancer cells. In this way, the novel nanoprobes can be used as promising theranostic agents for specific cancer therapy.

AB - A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis. MnO2 nanosheets fabricated on the surface of AgNPs served as efficient fluorescence quenchers of Dox. After being internalized into cancer cells, the fluorescence of Dox could be turned on gradually by intracellular glutathione (GSH) which reduces MnO2 into Mn2+ to release Dox. The synergetic effects of AgNP-induced apoptosis and subsequent Dox delivery resulted in enhanced cancer cell apoptosis. Annexin V-FITC/PI double staining, mitochondrial membrane potential (MMP) detection and reactive oxygen species (ROS) detection demonstrated the specific enhanced apoptosis of cancer cells. In this way, the novel nanoprobes can be used as promising theranostic agents for specific cancer therapy.

UR - https://www.scopus.com/pages/publications/84966270119

U2 - 10.1039/c6tb00438e

DO - 10.1039/c6tb00438e

M3 - 文章

AN - SCOPUS:84966270119

SN - 2050-750X

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SP - 2887

EP - 2894

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 17

ER -

A multifunctional core-shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy

Abstract

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