A multi-rotor near-infrared probe for high-sensitivity imaging of mitochondrial viscosity in epilepsy

Pengpeng Lu; Yuening Wang; Yan Huang; Limin Zhang

doi:10.1039/d6cc00108d

A multi-rotor near-infrared probe for high-sensitivity imaging of mitochondrial viscosity in epilepsy

Pengpeng Lu
, Yuening Wang
, Yan Huang^*
, Limin Zhang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Binzhou Medical College

Research output: Contribution to journal › Article › peer-review

Abstract

A mitochondria-targeted near-infrared fluorescent probe (Cy-TPE) is developed for mitochondrial viscosity imaging. A TICT-mediated multi-rotor architecture markedly enhances sensitivity to subtle viscosity changes, while persistent mitochondrial targeting enables long-term imaging. Cy-TPE visualizes elevated mitochondrial viscosity in epileptic neurons and mouse hippocampus in vivo.

Original language	English
Pages (from-to)	4037-4040
Number of pages	4
Journal	Chemical Communications
Volume	62
Issue number	13
DOIs	https://doi.org/10.1039/d6cc00108d
State	Published - 17 Feb 2026

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title = "A multi-rotor near-infrared probe for high-sensitivity imaging of mitochondrial viscosity in epilepsy",

abstract = "A mitochondria-targeted near-infrared fluorescent probe (Cy-TPE) is developed for mitochondrial viscosity imaging. A TICT-mediated multi-rotor architecture markedly enhances sensitivity to subtle viscosity changes, while persistent mitochondrial targeting enables long-term imaging. Cy-TPE visualizes elevated mitochondrial viscosity in epileptic neurons and mouse hippocampus in vivo.",

author = "Pengpeng Lu and Yuening Wang and Yan Huang and Limin Zhang",

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AU - Lu, Pengpeng

AU - Wang, Yuening

AU - Huang, Yan

AU - Zhang, Limin

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry, 2026

PY - 2026/2/17

Y1 - 2026/2/17

N2 - A mitochondria-targeted near-infrared fluorescent probe (Cy-TPE) is developed for mitochondrial viscosity imaging. A TICT-mediated multi-rotor architecture markedly enhances sensitivity to subtle viscosity changes, while persistent mitochondrial targeting enables long-term imaging. Cy-TPE visualizes elevated mitochondrial viscosity in epileptic neurons and mouse hippocampus in vivo.

AB - A mitochondria-targeted near-infrared fluorescent probe (Cy-TPE) is developed for mitochondrial viscosity imaging. A TICT-mediated multi-rotor architecture markedly enhances sensitivity to subtle viscosity changes, while persistent mitochondrial targeting enables long-term imaging. Cy-TPE visualizes elevated mitochondrial viscosity in epileptic neurons and mouse hippocampus in vivo.

UR - https://www.scopus.com/pages/publications/105030308139

U2 - 10.1039/d6cc00108d

DO - 10.1039/d6cc00108d

M3 - 文章

C2 - 41614622

AN - SCOPUS:105030308139

SN - 1359-7345

VL - 62

SP - 4037

EP - 4040

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

A multi-rotor near-infrared probe for high-sensitivity imaging of mitochondrial viscosity in epilepsy

Abstract

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