A method for constructing GLP-1 overexpression intestinal organoids

Zhi Yang Zeng; Jia Wei Lu; Xi Ya Cao; Xin Yue Wang; Da Li Li

doi:10.16288/j.yczz.20-423

A method for constructing GLP-1 overexpression intestinal organoids

Zhi Yang Zeng
, Jia Wei Lu
, Xi Ya Cao
, Xin Yue Wang
, Da Li Li

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

胰高血糖素样肽1 (glucagon-like peptide 1, GLP-1)作为一种肠促胰岛素,主要由肠道L细胞分泌,由于其能够有效促进胰岛素的释放从而降低血糖,因此GLP-1及其类似物在2型糖尿病的治疗上具有良好的应用前景。本研究优化了慢病毒感染类器官的方法,利用该方法成功构建了GLP-1过表达的小鼠小肠类器官(organoids)。结果显示该类器官分泌的GLP-1能够有效地提高野生型及糖尿病小鼠的葡萄糖耐受能力。因此,本研究构建的GLP-1过表达类器官可以为2型糖尿病的治疗提供一种新的策略。.

Original language	English
Pages (from-to)	694-703
Number of pages	10
Journal	Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji
Volume	43
Issue number	7
DOIs	https://doi.org/10.16288/j.yczz.20-423
State	Published - 20 Jul 2021

Keywords

GLP-1
intestinal organoids
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.16288/j.yczz.20-423

Cite this

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title = "A method for constructing GLP-1 overexpression intestinal organoids",

abstract = "胰高血糖素样肽1 (glucagon-like peptide 1, GLP-1)作为一种肠促胰岛素,主要由肠道L细胞分泌,由于其能够有效促进胰岛素的释放从而降低血糖,因此GLP-1及其类似物在2型糖尿病的治疗上具有良好的应用前景。本研究优化了慢病毒感染类器官的方法,利用该方法成功构建了GLP-1过表达的小鼠小肠类器官(organoids)。结果显示该类器官分泌的GLP-1能够有效地提高野生型及糖尿病小鼠的葡萄糖耐受能力。因此,本研究构建的GLP-1过表达类器官可以为2型糖尿病的治疗提供一种新的策略。.",

keywords = "GLP-1, intestinal organoids, type 2 diabetes",

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doi = "10.16288/j.yczz.20-423",

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AU - Zeng, Zhi Yang

AU - Lu, Jia Wei

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AU - Wang, Xin Yue

AU - Li, Da Li

PY - 2021/7/20

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N2 - 胰高血糖素样肽1 (glucagon-like peptide 1, GLP-1)作为一种肠促胰岛素,主要由肠道L细胞分泌,由于其能够有效促进胰岛素的释放从而降低血糖,因此GLP-1及其类似物在2型糖尿病的治疗上具有良好的应用前景。本研究优化了慢病毒感染类器官的方法,利用该方法成功构建了GLP-1过表达的小鼠小肠类器官(organoids)。结果显示该类器官分泌的GLP-1能够有效地提高野生型及糖尿病小鼠的葡萄糖耐受能力。因此,本研究构建的GLP-1过表达类器官可以为2型糖尿病的治疗提供一种新的策略。.

AB - 胰高血糖素样肽1 (glucagon-like peptide 1, GLP-1)作为一种肠促胰岛素,主要由肠道L细胞分泌,由于其能够有效促进胰岛素的释放从而降低血糖,因此GLP-1及其类似物在2型糖尿病的治疗上具有良好的应用前景。本研究优化了慢病毒感染类器官的方法,利用该方法成功构建了GLP-1过表达的小鼠小肠类器官(organoids)。结果显示该类器官分泌的GLP-1能够有效地提高野生型及糖尿病小鼠的葡萄糖耐受能力。因此,本研究构建的GLP-1过表达类器官可以为2型糖尿病的治疗提供一种新的策略。.

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IS - 7

ER -

A method for constructing GLP-1 overexpression intestinal organoids

Abstract

Keywords

UN SDGs

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