A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: Selective detection and quantification

Ting Guo; Lei Cui; Jiaoning Shen; Weiping Zhu; Yufang Xu; Xuhong Qian

doi:10.1039/c3cc45367g

A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: Selective detection and quantification

Ting Guo
, Lei Cui
, Jiaoning Shen
, Weiping Zhu
, Yufang Xu^*
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.

Original language	English
Pages (from-to)	10820-10822
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	92
DOIs	https://doi.org/10.1039/c3cc45367g
State	Published - 24 Oct 2013
Externally published	Yes

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10.1039/c3cc45367g

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title = "A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: Selective detection and quantification",

abstract = "A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.",

author = "Ting Guo and Lei Cui and Jiaoning Shen and Weiping Zhu and Yufang Xu and Xuhong Qian",

year = "2013",

month = oct,

day = "24",

doi = "10.1039/c3cc45367g",

language = "英语",

volume = "49",

pages = "10820--10822",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia

T2 - Selective detection and quantification

AU - Guo, Ting

AU - Cui, Lei

AU - Shen, Jiaoning

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Qian, Xuhong

PY - 2013/10/24

Y1 - 2013/10/24

N2 - A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.

AB - A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.

UR - https://www.scopus.com/pages/publications/84886544663

U2 - 10.1039/c3cc45367g

DO - 10.1039/c3cc45367g

M3 - 文章

C2 - 24121427

AN - SCOPUS:84886544663

SN - 1359-7345

VL - 49

SP - 10820

EP - 10822

JO - Chemical Communications

JF - Chemical Communications

IS - 92

ER -

A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: Selective detection and quantification

Abstract

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