A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

Jun Yuan; Yu Qiong Xu; Nan Nan Zhou; Rui Wang; Xu Hong Qian; Yu Fang Xu

doi:10.1039/c4ra10044a

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

Jun Yuan
, Yu Qiong Xu
, Nan Nan Zhou
, Rui Wang
, Xu Hong Qian
, Yu Fang Xu^*

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

Original language	English
Pages (from-to)	56207-56210
Number of pages	4
Journal	RSC Advances
Volume	4
Issue number	99
DOIs	https://doi.org/10.1039/c4ra10044a
State	Published - 2014
Externally published	Yes

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10.1039/c4ra10044a

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title = "A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging",

abstract = "Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.",

author = "Jun Yuan and Xu, \{Yu Qiong\} and Zhou, \{Nan Nan\} and Rui Wang and Qian, \{Xu Hong\} and Xu, \{Yu Fang\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2014.",

year = "2014",

doi = "10.1039/c4ra10044a",

language = "英语",

volume = "4",

pages = "56207--56210",

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T1 - A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

AU - Yuan, Jun

AU - Xu, Yu Qiong

AU - Zhou, Nan Nan

AU - Wang, Rui

AU - Qian, Xu Hong

AU - Xu, Yu Fang

PY - 2014

Y1 - 2014

N2 - Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

AB - Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

UR - https://www.scopus.com/pages/publications/84908616802

U2 - 10.1039/c4ra10044a

DO - 10.1039/c4ra10044a

M3 - 文章

AN - SCOPUS:84908616802

SN - 2046-2069

VL - 4

SP - 56207

EP - 56210

JO - RSC Advances

JF - RSC Advances

IS - 99

ER -

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

Abstract

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