A Hg2+ fluorescent chemosensor without interference from anions and Hg2+-imaging in living cells

Jiangli Fan; Kexin Guo; Xiaojun Peng; Jianjun Du; Jingyun Wang; Shiguo Sun; Honglin Li

doi:10.1016/j.snb.2009.08.002

A Hg²⁺ fluorescent chemosensor without interference from anions and Hg²⁺-imaging in living cells

Jiangli Fan
, Kexin Guo
, Xiaojun Peng^*
, Jianjun Du
, Jingyun Wang
, Shiguo Sun
, Honglin Li

^*Corresponding author for this work

Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

A fluorescent chemosensor, B2, for Hg²⁺ containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg²⁺ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg²⁺ in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg²⁺ in living cells.

Original language	English
Pages (from-to)	191-196
Number of pages	6
Journal	Sensors and Actuators B: Chemical
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2009.08.002
State	Published - 12 Oct 2009
Externally published	Yes

Keywords

Anions
Chemosensor
Fluorescence
Imaging
Living cells
Mercury ion

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10.1016/j.snb.2009.08.002

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abstract = "A fluorescent chemosensor, B2, for Hg2+ containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg2+ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg2+ in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg2+ in living cells.",

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year = "2009",

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T1 - A Hg2+ fluorescent chemosensor without interference from anions and Hg2+-imaging in living cells

AU - Fan, Jiangli

AU - Guo, Kexin

AU - Peng, Xiaojun

AU - Du, Jianjun

AU - Wang, Jingyun

AU - Sun, Shiguo

AU - Li, Honglin

PY - 2009/10/12

Y1 - 2009/10/12

N2 - A fluorescent chemosensor, B2, for Hg2+ containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg2+ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg2+ in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg2+ in living cells.

AB - A fluorescent chemosensor, B2, for Hg2+ containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg2+ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg2+ in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg2+ in living cells.

KW - Anions

KW - Chemosensor

KW - Fluorescence

KW - Imaging

KW - Living cells

KW - Mercury ion

UR - https://www.scopus.com/pages/publications/70349249279

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DO - 10.1016/j.snb.2009.08.002

M3 - 文章

AN - SCOPUS:70349249279

SN - 0925-4005

VL - 142

SP - 191

EP - 196

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

IS - 1

ER -

A Hg²⁺ fluorescent chemosensor without interference from anions and Hg²⁺-imaging in living cells

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Keywords

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