A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

Wenru Zhao; Hongti Zhang; Qianjun He; Yongsheng Li; Jinlou Gu; Liang Li; Hua Li; Jianlin Shi

doi:10.1039/c1cc12740c

A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

Wenru Zhao^*
, Hongti Zhang
, Qianjun He
, Yongsheng Li
, Jinlou Gu
, Liang Li
, Hua Li
, Jianlin Shi

^*Corresponding author for this work

East China University of Science and Technology
CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.

Original language	English
Pages (from-to)	9459-9461
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	33
DOIs	https://doi.org/10.1039/c1cc12740c
State	Published - 7 Sep 2011
Externally published	Yes

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abstract = "A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.",

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AU - Zhao, Wenru

AU - Zhang, Hongti

AU - He, Qianjun

AU - Li, Yongsheng

AU - Gu, Jinlou

AU - Li, Liang

AU - Li, Hua

AU - Shi, Jianlin

PY - 2011/9/7

Y1 - 2011/9/7

N2 - A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.

AB - A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.

UR - https://www.scopus.com/pages/publications/80051585553

U2 - 10.1039/c1cc12740c

DO - 10.1039/c1cc12740c

M3 - 文章

C2 - 21779606

AN - SCOPUS:80051585553

SN - 1359-7345

VL - 47

SP - 9459

EP - 9461

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

Abstract

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