A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

Xiao Luo; Jin Li; Jie Zhao; Luyan Gu; Xuhong Qian; Youjun Yang

doi:10.1016/j.cclet.2019.03.012

A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

Xiao Luo
, Jin Li
, Jie Zhao
, Luyan Gu
, Xuhong Qian^*
, Youjun Yang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Near infrared (NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding “NIR” is provided along with some recent breakthroughs of the field.

Original language	English
Pages (from-to)	839-846
Number of pages	8
Journal	Chinese Chemical Letters
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.cclet.2019.03.012
State	Published - Apr 2019

Keywords

Fluorescence
Near infrared
Polymethine cyanine
Rigidity
Steric protection

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10.1016/j.cclet.2019.03.012

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title = "A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes",

abstract = "Near infrared (NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding “NIR” is provided along with some recent breakthroughs of the field.",

keywords = "Fluorescence, Near infrared, Polymethine cyanine, Rigidity, Steric protection",

author = "Xiao Luo and Jin Li and Jie Zhao and Luyan Gu and Xuhong Qian and Youjun Yang",

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doi = "10.1016/j.cclet.2019.03.012",

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T1 - A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

AU - Luo, Xiao

AU - Li, Jin

AU - Zhao, Jie

AU - Gu, Luyan

AU - Qian, Xuhong

AU - Yang, Youjun

PY - 2019/4

Y1 - 2019/4

N2 - Near infrared (NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding “NIR” is provided along with some recent breakthroughs of the field.

AB - Near infrared (NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding “NIR” is provided along with some recent breakthroughs of the field.

KW - Fluorescence

KW - Near infrared

KW - Polymethine cyanine

KW - Rigidity

KW - Steric protection

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DO - 10.1016/j.cclet.2019.03.012

M3 - 文章

AN - SCOPUS:85062955406

SN - 1001-8417

VL - 30

SP - 839

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JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 4

ER -

A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

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Keywords

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