A framework of biomarkers for adipose tissue aging: A consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium

doi:10.1093/lifemedi/lnaf027

A framework of biomarkers for adipose tissue aging: A consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium

School of Life Sciences

Aging Biomarker Consortium
East China Normal University
Nanjing University
CAS - Shanghai Institute of Nutrition and Health
School of Life Science and Technology, Harbin Institute of Technology
Wuhan University
Fudan University
Chinese Academy of Medical Sciences
Shanghai Jiao Tong University
The First Affiliated Hospital of Nanjing Medical University
Beijing Hospital
CAS - Institute of Biophysics
Beijing Institute for Stem Cell and Regenerative Medicine
Huazhong University of Science and Technology
Peking University
Anhui Medical University
The University of Hong Kong
Nanfang Hospital
Shandong First Medical University & Shandong Academy of Medical Sciences
Central South University
CAS - Beijing Institute of Genomics
Zhengzhou University
Naval Medical University
Army Medical University
CAS - Institute of Zoology
Tongji University

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.

Original language	English
Article number	lnaf027
Journal	Life Medicine
Volume	4
Issue number	5
DOIs	https://doi.org/10.1093/lifemedi/lnaf027
State	Published - 1 Oct 2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/lifemedi/lnaf027

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title = "A framework of biomarkers for adipose tissue aging: A consensus statement by the Aging Biomarker Consortium",

abstract = "Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.",

author = "\{Aging Biomarker Consortium\} and Jian Yu and Yankang Zhang and Ting Zhang and Yan Bi and Yan Chen and Zheng Chen and Zhe Dai and Feifan Guo and Lixin Guo and Cheng Hu and Xiangqing Kong and Jian Li and Pingsheng Liu and Yong Liu and Jing Qu and Qiqun Tang and Congyi Wang and Liheng Wang and Jiqiu Wang and Jianping Weng and Aimin Xu and Lingyan Xu and Huijie Zhang and Jiajun Zhao and Jingjing Zhang and Weiqi Zhang and Tongjin Zhao and Weiping Zhang and Zhiming Zhu and Liu, \{Guang Hui\} and Guang Ning and Gang Pei and Li Qiang and Feng Liu and Xinran Ma",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s).",

year = "2025",

month = oct,

day = "1",

doi = "10.1093/lifemedi/lnaf027",

language = "英语",

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issn = "2755-1733",

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T1 - A framework of biomarkers for adipose tissue aging

T2 - A consensus statement by the Aging Biomarker Consortium

AU - Aging Biomarker Consortium

AU - Yu, Jian

AU - Zhang, Yankang

AU - Zhang, Ting

AU - Bi, Yan

AU - Chen, Yan

AU - Chen, Zheng

AU - Dai, Zhe

AU - Guo, Feifan

AU - Guo, Lixin

AU - Hu, Cheng

AU - Kong, Xiangqing

AU - Li, Jian

AU - Liu, Pingsheng

AU - Liu, Yong

AU - Qu, Jing

AU - Tang, Qiqun

AU - Wang, Congyi

AU - Wang, Liheng

AU - Wang, Jiqiu

AU - Weng, Jianping

AU - Xu, Aimin

AU - Xu, Lingyan

AU - Zhang, Huijie

AU - Zhao, Jiajun

AU - Zhang, Jingjing

AU - Zhang, Weiqi

AU - Zhao, Tongjin

AU - Zhang, Weiping

AU - Zhu, Zhiming

AU - Liu, Guang Hui

AU - Ning, Guang

AU - Pei, Gang

AU - Qiang, Li

AU - Liu, Feng

AU - Ma, Xinran

PY - 2025/10/1

Y1 - 2025/10/1

N2 - Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.

AB - Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.

UR - https://www.scopus.com/pages/publications/105019542327

U2 - 10.1093/lifemedi/lnaf027

DO - 10.1093/lifemedi/lnaf027

M3 - 文献综述

AN - SCOPUS:105019542327

SN - 2755-1733

VL - 4

JO - Life Medicine

JF - Life Medicine

IS - 5

M1 - lnaf027

ER -

A framework of biomarkers for adipose tissue aging: A consensus statement by the Aging Biomarker Consortium

Abstract

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