A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

Linfeng Xing; Bin Wang; Jin Li; Xinjian Guo; Xicun Lu; Xiaohua Chen; Haitao Sun; Zhenrong Sun; Xiao Luo; Suhua Qi; Xuhong Qian; Youjun Yang

doi:10.1021/jacs.2c00094

A Fluorogenic ONOO^--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

Linfeng Xing
, Bin Wang
, Jin Li
, Xinjian Guo
, Xicun Lu
, Xiaohua Chen
, Haitao Sun
, Zhenrong Sun
, Xiao Luo^*
, Suhua Qi^*
, Xuhong Qian^*
, Youjun Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Ischemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO-. Direct radical scavenging is difficult because of their high reactivity. ONOO- is longer-lived than the radicals in the biological milieu. Scavenging ONOO- suppresses radical generation preventively. CO is neuroprotective during ischemia. With the scaffold of carbon-caged xanthene, we designed an OONO-triggered CO donor (PCOD585). Notably, PCOD585 exhibited a concomitant fluorescence turn-on upon ONOO-detection, facilitating microscopic monitoring. PCOD585 was cytoprotective in oxygen-glucose deprivation (OGD)-insulted PC-12 cells. It was permeable to the blood-brain barrier and further exhibited neuroprotective effects to MCAO rats by reducing infarction volume, cell apoptosis, and brain edema.

Original language	English
Pages (from-to)	2114-2119
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	144
Issue number	5
DOIs	https://doi.org/10.1021/jacs.2c00094
State	Published - 9 Feb 2022

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title = "A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage",

abstract = "Ischemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO-. Direct radical scavenging is difficult because of their high reactivity. ONOO- is longer-lived than the radicals in the biological milieu. Scavenging ONOO- suppresses radical generation preventively. CO is neuroprotective during ischemia. With the scaffold of carbon-caged xanthene, we designed an OONO-triggered CO donor (PCOD585). Notably, PCOD585 exhibited a concomitant fluorescence turn-on upon ONOO-detection, facilitating microscopic monitoring. PCOD585 was cytoprotective in oxygen-glucose deprivation (OGD)-insulted PC-12 cells. It was permeable to the blood-brain barrier and further exhibited neuroprotective effects to MCAO rats by reducing infarction volume, cell apoptosis, and brain edema.",

author = "Linfeng Xing and Bin Wang and Jin Li and Xinjian Guo and Xicun Lu and Xiaohua Chen and Haitao Sun and Zhenrong Sun and Xiao Luo and Suhua Qi and Xuhong Qian and Youjun Yang",

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doi = "10.1021/jacs.2c00094",

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T1 - A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

AU - Xing, Linfeng

AU - Wang, Bin

AU - Li, Jin

AU - Guo, Xinjian

AU - Lu, Xicun

AU - Chen, Xiaohua

AU - Sun, Haitao

AU - Sun, Zhenrong

AU - Luo, Xiao

AU - Qi, Suhua

AU - Qian, Xuhong

AU - Yang, Youjun

PY - 2022/2/9

Y1 - 2022/2/9

N2 - Ischemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO-. Direct radical scavenging is difficult because of their high reactivity. ONOO- is longer-lived than the radicals in the biological milieu. Scavenging ONOO- suppresses radical generation preventively. CO is neuroprotective during ischemia. With the scaffold of carbon-caged xanthene, we designed an OONO-triggered CO donor (PCOD585). Notably, PCOD585 exhibited a concomitant fluorescence turn-on upon ONOO-detection, facilitating microscopic monitoring. PCOD585 was cytoprotective in oxygen-glucose deprivation (OGD)-insulted PC-12 cells. It was permeable to the blood-brain barrier and further exhibited neuroprotective effects to MCAO rats by reducing infarction volume, cell apoptosis, and brain edema.

AB - Ischemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO-. Direct radical scavenging is difficult because of their high reactivity. ONOO- is longer-lived than the radicals in the biological milieu. Scavenging ONOO- suppresses radical generation preventively. CO is neuroprotective during ischemia. With the scaffold of carbon-caged xanthene, we designed an OONO-triggered CO donor (PCOD585). Notably, PCOD585 exhibited a concomitant fluorescence turn-on upon ONOO-detection, facilitating microscopic monitoring. PCOD585 was cytoprotective in oxygen-glucose deprivation (OGD)-insulted PC-12 cells. It was permeable to the blood-brain barrier and further exhibited neuroprotective effects to MCAO rats by reducing infarction volume, cell apoptosis, and brain edema.

UR - https://www.scopus.com/pages/publications/85124153760

U2 - 10.1021/jacs.2c00094

DO - 10.1021/jacs.2c00094

M3 - 文章

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AN - SCOPUS:85124153760

SN - 0002-7863

VL - 144

SP - 2114

EP - 2119

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 5

ER -

A Fluorogenic ONOO^--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

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