A Facile Method for the Synthesis of 3-Alkyloxindole

Tai Ping Du; Gang Guo Zhu; Jian Zhou

doi:10.2174/157017812800167420

A Facile Method for the Synthesis of 3-Alkyloxindole

Tai Ping Du
, Gang Guo Zhu^*
, Jian Zhou

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Zhejiang Normal University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH ₄.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Letters in Organic Chemistry
Volume	9
Issue number	3
DOIs	https://doi.org/10.2174/157017812800167420
State	Published - Mar 2012

Keywords

3-alkenyloxindoles
3-alkyloxindoles
Benzylamine
Carbonyl compounds
Conjugate reduction
Knoevenagel condensations

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10.2174/157017812800167420

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title = "A Facile Method for the Synthesis of 3-Alkyloxindole",

abstract = "Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH 4.",

keywords = "3-alkenyloxindoles, 3-alkyloxindoles, Benzylamine, Carbonyl compounds, Conjugate reduction, Knoevenagel condensations",

author = "Du, \{Tai Ping\} and Zhu, \{Gang Guo\} and Jian Zhou",

year = "2012",

month = mar,

doi = "10.2174/157017812800167420",

language = "英语",

volume = "9",

pages = "225--232",

journal = "Letters in Organic Chemistry",

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T1 - A Facile Method for the Synthesis of 3-Alkyloxindole

AU - Du, Tai Ping

AU - Zhu, Gang Guo

AU - Zhou, Jian

PY - 2012/3

Y1 - 2012/3

N2 - Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH 4.

AB - Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH 4.

KW - 3-alkenyloxindoles

KW - 3-alkyloxindoles

KW - Benzylamine

KW - Carbonyl compounds

KW - Conjugate reduction

KW - Knoevenagel condensations

UR - https://www.scopus.com/pages/publications/84860592876

U2 - 10.2174/157017812800167420

DO - 10.2174/157017812800167420

M3 - 文章

AN - SCOPUS:84860592876

SN - 1570-1786

VL - 9

SP - 225

EP - 232

JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

IS - 3

ER -

A Facile Method for the Synthesis of 3-Alkyloxindole

Abstract

Keywords

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