A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Jinrui Xun; Zhichao Zhang; Bo Lv; Defen Lu; Haoxiang Yang; Guijun Shang; Jay Xiaojun Tan

doi:10.1038/s44319-023-00045-x

A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Jinrui Xun, Zhichao Zhang, Bo Lv, Defen Lu, Haoxiang Yang, Guijun Shang^*, Jay Xiaojun Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

Original language	English
Pages (from-to)	544-569
Number of pages	26
Journal	EMBO Reports
Volume	25
Issue number	2
DOIs	https://doi.org/10.1038/s44319-023-00045-x
State	Published - 13 Feb 2024
Externally published	Yes

Keywords

Ion Channel
Membrane Trafficking
Noncanonical Autophagy
STING
Vesicle Deacidification

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10.1038/s44319-023-00045-x

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title = "A conserved ion channel function of STING mediates noncanonical autophagy and cell death",

abstract = "Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)",

keywords = "Ion Channel, Membrane Trafficking, Noncanonical Autophagy, STING, Vesicle Deacidification",

author = "Jinrui Xun and Zhichao Zhang and Bo Lv and Defen Lu and Haoxiang Yang and Guijun Shang and Tan, \{Jay Xiaojun\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024..",

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doi = "10.1038/s44319-023-00045-x",

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TY - JOUR

T1 - A conserved ion channel function of STING mediates noncanonical autophagy and cell death

AU - Xun, Jinrui

AU - Zhang, Zhichao

AU - Lv, Bo

AU - Lu, Defen

AU - Yang, Haoxiang

AU - Shang, Guijun

AU - Tan, Jay Xiaojun

N1 - Publisher Copyright: © The Author(s) 2024..

PY - 2024/2/13

Y1 - 2024/2/13

N2 - Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

AB - Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

KW - Ion Channel

KW - Membrane Trafficking

KW - Noncanonical Autophagy

KW - STING

KW - Vesicle Deacidification

UR - https://www.scopus.com/pages/publications/85185198461

U2 - 10.1038/s44319-023-00045-x

DO - 10.1038/s44319-023-00045-x

M3 - 文章

C2 - 38177926

AN - SCOPUS:85185198461

SN - 1469-221X

VL - 25

SP - 544

EP - 569

JO - EMBO Reports

JF - EMBO Reports

IS - 2

ER -

A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Abstract

Keywords

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