TY - JOUR
T1 - A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population
AU - Zhang, Rong
AU - Lu, Jingyi
AU - Hu, Cheng
AU - Wang, Congrong
AU - Yu, Weihui
AU - Ma, Xiaojing
AU - Bao, Yuqian
AU - Xiang, Kunsan
AU - Guan, Youfei
AU - Jia, Weiping
PY - 2011/5
Y1 - 2011/5
N2 - Variants of the human CYP4A11, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of CYP4A11 on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype-phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06-1.81, P0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (Β3.17, P0.0011) and diastolic blood pressure (Β1.75, P0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.
AB - Variants of the human CYP4A11, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of CYP4A11 on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype-phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06-1.81, P0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (Β3.17, P0.0011) and diastolic blood pressure (Β1.75, P0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.
KW - CYP4A11
KW - Chinese
KW - single nucleotide polymorphism
UR - https://www.scopus.com/pages/publications/79955639190
U2 - 10.1038/hr.2011.8
DO - 10.1038/hr.2011.8
M3 - 文章
C2 - 21326303
AN - SCOPUS:79955639190
SN - 0916-9636
VL - 34
SP - 645
EP - 648
JO - Hypertension Research
JF - Hypertension Research
IS - 5
ER -