Abstract
Triangulation method: The catalytic enantioselective cyclopropanation of multisubstituted olefins with phenyliodonium ylide malonate has been achieved in the presence of a chiral bisoxazoline copper(I) complex (see scheme). A wide range of substrates undergo the reaction to provide optically active 1,1-cyclopropane diesters in high yield with up to >99 %-ee. A rationale for the enantioselective induction has been proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 11620-11623 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 46 |
| DOIs | |
| State | Published - 12 Nov 2012 |
| Externally published | Yes |
Keywords
- asymmetric catalysis
- carbenes
- copper
- cyclopropanation
- homogeneous catalysis
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