A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

Mengmeng Jiang; Zhuozhao Zheng; Xuan Wang; Yanhao Chen; Jing Qu; Qiurong Ding; Weiqi Zhang; You Shuo Liu; Jichun Yang; Weiqing Tang; Yunlong Hou; Jinhan He; Lin Wang; Pengyu Huang; Lin Chen Li; Zhiying He; Qiang Gao; Qian Lu; Lai Wei; Yan Jiang Wang; Zhenyu Ju; Jian Gao Fan; Xiong Zhong Ruan; Youfei Guan; Guang Hui Liu; Gang Pei; Jian Li; Yunfang Wang

doi:10.1093/lifemedi/lnae004

A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

Mengmeng Jiang
, Zhuozhao Zheng
, Xuan Wang
, Yanhao Chen
, Jing Qu^*
, Qiurong Ding^*
, Weiqi Zhang^*
, You Shuo Liu^*
, Jichun Yang^*
, Weiqing Tang^*
, Yunlong Hou^*
, Jinhan He^*
, Lin Wang^*
, Pengyu Huang^*
, Lin Chen Li^*
, Zhiying He^*
, Qiang Gao^*
, Qian Lu^*
, Lai Wei^*
, Yan Jiang Wang^*

Zhenyu Ju^*, Jian Gao Fan^*, Xiong Zhong Ruan^*, Youfei Guan^*, Guang Hui Liu^*, Gang Pei^*, Jian Li^*, Yunfang Wang^*

^*Corresponding author for this work

CAS - Institute of Zoology
Chinese Academy of Sciences
Tsinghua University
CAS - Shanghai Institute of Nutrition and Health
CAS - Beijing Institute of Genomics
Central South University
Peking University
Shanghai University
Yiling Pharmaceutical Academician Workstation
Sichuan University
Xijing Hospital
Ministry of Education of the People's Republic of China
Tongji University
Fudan University
Third Military Medical University
Jinan University
Shanghai Jiao Tong University
Chongqing Medical University
Dalian Medical University
University of Chinese Academy of Sciences
Chinese Academy of Medical Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

Original language	English
Article number	004
Journal	Life Medicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.1093/lifemedi/lnae004
State	Published - 1 Feb 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/lifemedi/lnae004

Cite this

Jiang, M., Zheng, Z., Wang, X., Chen, Y., Qu, J., Ding, Q., Zhang, W., Liu, Y. S., Yang, J., Tang, W., Hou, Y., He, J., Wang, L., Huang, P., Li, L. C., He, Z., Gao, Q., Lu, Q., Wei, L., ... Wang, Y. (2024). A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement. Life Medicine, 3(1), Article 004. https://doi.org/10.1093/lifemedi/lnae004

@article{0615b7c24883480c94422d81dd13603c,

title = "A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement",

abstract = "In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.",

author = "Mengmeng Jiang and Zhuozhao Zheng and Xuan Wang and Yanhao Chen and Jing Qu and Qiurong Ding and Weiqi Zhang and Liu, \{You Shuo\} and Jichun Yang and Weiqing Tang and Yunlong Hou and Jinhan He and Lin Wang and Pengyu Huang and Li, \{Lin Chen\} and Zhiying He and Qiang Gao and Qian Lu and Lai Wei and Wang, \{Yan Jiang\} and Zhenyu Ju and Fan, \{Jian Gao\} and Ruan, \{Xiong Zhong\} and Youfei Guan and Liu, \{Guang Hui\} and Gang Pei and Jian Li and Yunfang Wang",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.",

year = "2024",

month = feb,

day = "1",

doi = "10.1093/lifemedi/lnae004",

language = "英语",

volume = "3",

journal = "Life Medicine",

issn = "2755-1733",

publisher = "Oxford University Press",

number = "1",

}

Jiang, M, Zheng, Z, Wang, X, Chen, Y, Qu, J, Ding, Q, Zhang, W, Liu, YS, Yang, J, Tang, W, Hou, Y, He, J, Wang, L, Huang, P, Li, LC, He, Z, Gao, Q, Lu, Q, Wei, L, Wang, YJ, Ju, Z, Fan, JG, Ruan, XZ, Guan, Y, Liu, GH, Pei, G, Li, J & Wang, Y 2024, 'A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement', Life Medicine, vol. 3, no. 1, 004. https://doi.org/10.1093/lifemedi/lnae004

TY - JOUR

T1 - A biomarker framework for liver aging

T2 - the Aging Biomarker Consortium consensus statement

AU - Jiang, Mengmeng

AU - Zheng, Zhuozhao

AU - Wang, Xuan

AU - Chen, Yanhao

AU - Qu, Jing

AU - Ding, Qiurong

AU - Zhang, Weiqi

AU - Liu, You Shuo

AU - Yang, Jichun

AU - Tang, Weiqing

AU - Hou, Yunlong

AU - He, Jinhan

AU - Wang, Lin

AU - Huang, Pengyu

AU - Li, Lin Chen

AU - He, Zhiying

AU - Gao, Qiang

AU - Lu, Qian

AU - Wei, Lai

AU - Wang, Yan Jiang

AU - Ju, Zhenyu

AU - Fan, Jian Gao

AU - Ruan, Xiong Zhong

AU - Guan, Youfei

AU - Liu, Guang Hui

AU - Pei, Gang

AU - Li, Jian

AU - Wang, Yunfang

PY - 2024/2/1

Y1 - 2024/2/1

N2 - In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

AB - In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

UR - https://www.scopus.com/pages/publications/85202477078

U2 - 10.1093/lifemedi/lnae004

DO - 10.1093/lifemedi/lnae004

M3 - 文章

AN - SCOPUS:85202477078

SN - 2755-1733

VL - 3

JO - Life Medicine

JF - Life Medicine

IS - 1

M1 - 004

ER -

A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

Abstract

UN SDGs

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