A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes

Xiaoyuan Wu; Kangjie Zhao; Mengyao Liu; Shixiang Ding; Xuyang Li; Yuri Lu; Ruohan Wang; Ziyan Zhao; Liwen Qian; Yang Yang; Jing Wu; Leilei Huang; Chunqi Shi; Yuhong Wei; Yue Lu; Ningzi Guan; Haifeng Ye; Jinghong Chen; Runxi Zhang

doi:10.1109/ISSCC49663.2026.11409025

A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes

Xiaoyuan Wu
, Kangjie Zhao
, Mengyao Liu
, Shixiang Ding
, Xuyang Li
, Yuri Lu
, Ruohan Wang
, Ziyan Zhao
, Liwen Qian
, Yang Yang
, Jing Wu
, Leilei Huang^*
, Chunqi Shi^*
, Yuhong Wei
, Yue Lu
, Ningzi Guan
, Haifeng Ye^*
, Jinghong Chen
, Runxi Zhang^*

^*Corresponding author for this work

East China Normal University
University of Houston

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Conventional management of type-1 diabetes (T1D) relies on finger-prick blood sampling or electrochemical methods, which prevent continuous monitoring and treatment. This paper presents a novel epidermal pasting bioelectronic device (PBD). The device integrates a 19fA-resolution bioluminescence analog front-end (BAFE) with TDM-SAR calibration and a hybrid-mode LED driver. It enables closed-loop realtime detection and precision treatment for T1D. The battery life reaches 48 days.

Original language	English
Title of host publication	2026 IEEE International Solid-State Circuits Conference, ISSCC 2026
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	498-500
Number of pages	3
ISBN (Electronic)	9798331589363
DOIs	https://doi.org/10.1109/ISSCC49663.2026.11409025
State	Published - 2026
Event	2026 IEEE International Solid-State Circuits Conference, ISSCC 2026 - San Francisco, United States Duration: 15 Feb 2026 → 19 Feb 2026

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	69
ISSN (Print)	0193-6530

Conference

Conference	2026 IEEE International Solid-State Circuits Conference, ISSCC 2026
Country/Territory	United States
City	San Francisco
Period	15/02/26 → 19/02/26

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1109/ISSCC49663.2026.11409025

Cite this

Wu, X., Zhao, K., Liu, M., Ding, S., Li, X., Lu, Y., Wang, R., Zhao, Z., Qian, L., Yang, Y., Wu, J., Huang, L., Shi, C., Wei, Y., Lu, Y., Guan, N., Ye, H., Chen, J., & Zhang, R. (2026). A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes. In 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026 (pp. 498-500). (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 69). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC49663.2026.11409025

Wu, Xiaoyuan ; Zhao, Kangjie ; Liu, Mengyao et al. / A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes. 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026. Institute of Electrical and Electronics Engineers Inc., 2026. pp. 498-500 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).

@inproceedings{c334aa83785a4b90b4c317c3556d8102,

title = "A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes",

abstract = "Conventional management of type-1 diabetes (T1D) relies on finger-prick blood sampling or electrochemical methods, which prevent continuous monitoring and treatment. This paper presents a novel epidermal pasting bioelectronic device (PBD). The device integrates a 19fA-resolution bioluminescence analog front-end (BAFE) with TDM-SAR calibration and a hybrid-mode LED driver. It enables closed-loop realtime detection and precision treatment for T1D. The battery life reaches 48 days.",

author = "Xiaoyuan Wu and Kangjie Zhao and Mengyao Liu and Shixiang Ding and Xuyang Li and Yuri Lu and Ruohan Wang and Ziyan Zhao and Liwen Qian and Yang Yang and Jing Wu and Leilei Huang and Chunqi Shi and Yuhong Wei and Yue Lu and Ningzi Guan and Haifeng Ye and Jinghong Chen and Runxi Zhang",

note = "Publisher Copyright: {\textcopyright} 2026 IEEE.; 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026 ; Conference date: 15-02-2026 Through 19-02-2026",

year = "2026",

doi = "10.1109/ISSCC49663.2026.11409025",

language = "英语",

series = "Digest of Technical Papers - IEEE International Solid-State Circuits Conference",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "498--500",

booktitle = "2026 IEEE International Solid-State Circuits Conference, ISSCC 2026",

address = "美国",

}

Wu, X, Zhao, K, Liu, M, Ding, S, Li, X, Lu, Y, Wang, R, Zhao, Z, Qian, L, Yang, Y, Wu, J, Huang, L, Shi, C, Wei, Y, Lu, Y , Guan, N , Ye, H, Chen, J & Zhang, R 2026, A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes. in 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026. Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 69, Institute of Electrical and Electronics Engineers Inc., pp. 498-500, 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026, San Francisco, United States, 15/02/26. https://doi.org/10.1109/ISSCC49663.2026.11409025

A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes. / Wu, Xiaoyuan; Zhao, Kangjie; Liu, Mengyao et al.
2026 IEEE International Solid-State Circuits Conference, ISSCC 2026. Institute of Electrical and Electronics Engineers Inc., 2026. p. 498-500 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 69).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes

AU - Wu, Xiaoyuan

AU - Zhao, Kangjie

AU - Liu, Mengyao

AU - Ding, Shixiang

AU - Li, Xuyang

AU - Lu, Yuri

AU - Wang, Ruohan

AU - Zhao, Ziyan

AU - Qian, Liwen

AU - Yang, Yang

AU - Wu, Jing

AU - Huang, Leilei

AU - Shi, Chunqi

AU - Wei, Yuhong

AU - Lu, Yue

AU - Guan, Ningzi

AU - Ye, Haifeng

AU - Chen, Jinghong

AU - Zhang, Runxi

PY - 2026

Y1 - 2026

N2 - Conventional management of type-1 diabetes (T1D) relies on finger-prick blood sampling or electrochemical methods, which prevent continuous monitoring and treatment. This paper presents a novel epidermal pasting bioelectronic device (PBD). The device integrates a 19fA-resolution bioluminescence analog front-end (BAFE) with TDM-SAR calibration and a hybrid-mode LED driver. It enables closed-loop realtime detection and precision treatment for T1D. The battery life reaches 48 days.

AB - Conventional management of type-1 diabetes (T1D) relies on finger-prick blood sampling or electrochemical methods, which prevent continuous monitoring and treatment. This paper presents a novel epidermal pasting bioelectronic device (PBD). The device integrates a 19fA-resolution bioluminescence analog front-end (BAFE) with TDM-SAR calibration and a hybrid-mode LED driver. It enables closed-loop realtime detection and precision treatment for T1D. The battery life reaches 48 days.

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M3 - 会议稿件

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BT - 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026

Y2 - 15 February 2026 through 19 February 2026

ER -

Wu X, Zhao K, Liu M, Ding S, Li X, Lu Y et al. A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes. In 2026 IEEE International Solid-State Circuits Conference, ISSCC 2026. Institute of Electrical and Electronics Engineers Inc. 2026. p. 498-500. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC49663.2026.11409025

A 48-Day-Duration Pasting Bioelectronic Device Realizing Closed-Loop Realtime Detection and Precision Treatment for Type-1 Diabetes

Abstract

Publication series

Conference

UN SDGs

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