1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

Zhi Fu Tao; Xuhong Qian; Dongzhi Wei

doi:10.1016/0143-7208(95)00105-0

1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

Zhi Fu Tao
, Xuhong Qian^*
, Dongzhi Wei

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

Original language	English
Pages (from-to)	245-251
Number of pages	7
Journal	Dyes and Pigments
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/0143-7208(95)00105-0
State	Published - Jul 1996
Externally published	Yes

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title = "1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers",

abstract = "Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.",

author = "Tao, \{Zhi Fu\} and Xuhong Qian and Dongzhi Wei",

year = "1996",

month = jul,

doi = "10.1016/0143-7208(95)00105-0",

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volume = "31",

pages = "245--251",

journal = "Dyes and Pigments",

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T1 - 1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

AU - Tao, Zhi Fu

AU - Qian, Xuhong

AU - Wei, Dongzhi

PY - 1996/7

Y1 - 1996/7

N2 - Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

AB - Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

UR - https://www.scopus.com/pages/publications/0030194657

U2 - 10.1016/0143-7208(95)00105-0

DO - 10.1016/0143-7208(95)00105-0

M3 - 文章

AN - SCOPUS:0030194657

SN - 0143-7208

VL - 31

SP - 245

EP - 251

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 3

ER -

1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

Abstract

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