1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation

Shaoyong Ke; Fengyi Liu; Ni Wang; Qing Yang; Xuhong Qian

doi:10.1016/j.bmcl.2008.11.095

1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation

Shaoyong Ke
, Fengyi Liu
, Ni Wang
, Qing Yang^*
, Xuhong Qian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure-activity relationships (SAR) of these compounds are discussed.

Original language	English
Pages (from-to)	332-335
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2008.11.095
State	Published - 15 Jan 2009
Externally published	Yes

Keywords

1,3,4-Oxadiazolines
Chitin biosynthesis
Potential inhibitors

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10.1016/j.bmcl.2008.11.095

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abstract = "Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure-activity relationships (SAR) of these compounds are discussed.",

keywords = "1,3,4-Oxadiazolines, Chitin biosynthesis, Potential inhibitors",

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T2 - Design, synthesis and biological evaluation

AU - Ke, Shaoyong

AU - Liu, Fengyi

AU - Wang, Ni

AU - Yang, Qing

AU - Qian, Xuhong

PY - 2009/1/15

Y1 - 2009/1/15

N2 - Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure-activity relationships (SAR) of these compounds are discussed.

AB - Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure-activity relationships (SAR) of these compounds are discussed.

KW - 1,3,4-Oxadiazolines

KW - Chitin biosynthesis

KW - Potential inhibitors

UR - https://www.scopus.com/pages/publications/57749104658

U2 - 10.1016/j.bmcl.2008.11.095

DO - 10.1016/j.bmcl.2008.11.095

M3 - 文章

C2 - 19091556

AN - SCOPUS:57749104658

SN - 0960-894X

VL - 19

SP - 332

EP - 335

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation

Abstract

Keywords

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