1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Min Qi Hu; Heng Li; Ying Lin; Ying Zhang; Jie Tang; Jian Ping Zuo; Li Fang Yu; Xian Kun Tong; Wei Tang; Fan Yang

doi:10.1039/d0ra08442e

1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Min Qi Hu
, Heng Li
, Ying Lin
, Ying Zhang
, Jie Tang
, Jian Ping Zuo
, Li Fang Yu
, Xian Kun Tong^*
, Wei Tang^*
, Fan Yang^*

^*Corresponding author for this work

East China Normal University
CAS - Shanghai Institute of Materia Medica
University of Chinese Academy of Sciences
Shanghai Greenchem and Biotech Co. Ltd.

Research output: Contribution to journal › Article › peer-review

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

Original language	English
Pages (from-to)	43299-43311
Number of pages	13
Journal	RSC Advances
Volume	10
Issue number	71
DOIs	https://doi.org/10.1039/d0ra08442e
State	Published - 20 Nov 2020

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SDG 3 Good Health and Well-being

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10.1039/d0ra08442e

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title = "1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors",

abstract = "Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50\% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.",

author = "Hu, \{Min Qi\} and Heng Li and Ying Lin and Ying Zhang and Jie Tang and Zuo, \{Jian Ping\} and Yu, \{Li Fang\} and Tong, \{Xian Kun\} and Wei Tang and Fan Yang",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2020",

month = nov,

day = "20",

doi = "10.1039/d0ra08442e",

language = "英语",

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T1 - 1-Phenyl-

T2 - N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

AU - Hu, Min Qi

AU - Li, Heng

AU - Lin, Ying

AU - Zhang, Ying

AU - Tang, Jie

AU - Zuo, Jian Ping

AU - Yu, Li Fang

AU - Tong, Xian Kun

AU - Tang, Wei

AU - Yang, Fan

PY - 2020/11/20

Y1 - 2020/11/20

N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

AB - Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

UR - https://www.scopus.com/pages/publications/85098461946

U2 - 10.1039/d0ra08442e

DO - 10.1039/d0ra08442e

M3 - 文章

AN - SCOPUS:85098461946

SN - 2046-2069

VL - 10

SP - 43299

EP - 43311

JO - RSC Advances

JF - RSC Advances

IS - 71

ER -

1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Abstract

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