Abstract
When body is disturbed by abnormal light/dark schedules，it usually takes several days to resynchronize the internal clock with the external clock. To investigate the effect of repetitive phase shifts in a short period on circadian behavior of mice，C57BL/6 mice are treated with repetitive 6 h advance phase shift ( + 6，equivalent to crossing 6 time zones to eastward) and delay phase shift (- 6， equivalent to crossing 6 time zones westward)，and monitored by wheel running activity continuously for evaluation of behavioral adaptation. The results show that the number of days for re-entrainmcnt decreases gradually irrespective of the phase shift direction ( + 6 phase shifts： from (5. 33士0. 21 )d to (1. 29士0. 18)d，^<0. 001； -6 phase shifts： from (5. 83士0. 40)d to (3. 00士0. 37)d，p<0. 001). However, -6 phase shifts after the treatment of multiple +6 phase shifts do not further improve the adaptive ability ((5. 71 士0. 61)d vs. (5. 33士0. 21)d, p = 0. 95). +6 phase shifts following multiple -6 phase shifts even retard behavioral adaptation ((13. 14士0. 55)d vs. (5. 83士0. 40)d，p<0. 001). These results implicate that adaptation to multiple advance or delay phase shifts within a short period is gradually enhanced in mice，while the adaptation is not enhanced or even decreased when challenged by bidirectional phase shifts.
| Translated title of the contribution | Influence of repetitive 6 h phase shifts treatment on circadian behavior of mice |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 454-459 |
| Number of pages | 6 |
| Journal | Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology |
| Volume | 62 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2022 |
| Externally published | Yes |