Abstract
DMSN@Ag/Au composites,with DMSN(dendritic mesoporous silica nanosphere),as the support and Au/Ag nanoparticles homogeneously loading on the surface,were employed as MALDI(matrix-assisted laser desorption/ionization)matrices. These composites enable highly sensitive MALDI metabolic analysis with a detection limit of 0.005 mg/mL. Moreover,these composites demonstrated good reproducibility in detection and provided an intrinsic Au+ signal as a reference to enhance the accuracy of quantitative analysis. Additionally,DMSN@Ag/Au facilitated Ag+ addition to the analyte and assisted in metabolite identification process. The composites are expected to serve as a new generation of multifunctional MALDI matrix and provide new ideas for clinical mass spectrometry analysis.
| Translated title of the contribution | Plasmonic Composites Aid Semi-quantitative Analysis and Identification of Low-molecular-weight Metabolites by Mass Spectrometry |
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| Original language | Chinese (Traditional) |
| Article number | 20240325 |
| Journal | Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities |
| Volume | 45 |
| Issue number | 11 |
| DOIs | |
| State | Published - 10 Nov 2024 |