Abstract
Aim To investigate the therapeutic effects of corylifol A (CYA) on Lewis lung Carcinoma (LLC) cachexia mice and its ameliorating effects on myotube atrophy induced by LLC cell-conditioned medium (LLC CM) in vitro, and to explore the mechanisms. Methods The Cancer cachexia was induced by subeu-taneous inoculation of LLC cells to C57BL/6J mice. The effects of CYA (10, 20 mg • kg"1 • d"1, i. p.) on the cachexia Symptoms and survival time of cachexia mice were observed. The effects of 2. 5 or 5 p,mol • L~ CYA on myotube atrophy of C2C12 induced by LLC CM were observed. The effects of CYA on its pos-sible target the serine/threonine-protein kinase TAOl (TAOK1) and downstream signaling pathways were detected using Western blot. The influence of TAOK1 knockout on the ameliorating effects of CYA on myotube atrophy was observed. Results CYA could sig-nificantly prolong the survival time of tumor-bearing mice and ameliorate the muscle atrophy associated with LLC. The effects of CYA on myotube atrophy are related to its regulation of TAOK1. The effects of CYA could be reduced by knockout of TAOK1. Conclusions CYA improves the survival of LLC cachexia mice and ameliorates the related skeletal muscle atrophy. The mechanism of CYA is related to its inhibition on TAOK1 and downstream signaling pathways.
| Translated title of the contribution | Corylifol A ameliorates Lewis lung Carcinoma induced cachexia in mice |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 1672-1679 |
| Number of pages | 8 |
| Journal | Chinese Pharmacological Bulletin |
| Volume | 41 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2025 |
